ArticleEuropean journal of nutrition2011
Vitamin C levels in blood are influenced by polymorphisms in glutathione S-transferases.
Article in European journal of nutrition, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Genetic Variants Shaping Inter-individual Differences in Response to Dietary Intakes-A Narrative Review of the Case of Vitamins.Frontiers in nutrition · 2020Pooled it
- Serum vitamin C and other biomarkers differ by genotype of phase 2 enzyme genes GSTM1 and GSTT1.The American journal of clinical nutrition · 2011Trial
- The Study of Nutrient Intake and Adolescent Girls' Quality of Life in a Rural Area of Indonesia.Children (Basel, Switzerland) · 2022Article
- Vitamin C and Cardiovascular Disease: An Update.Antioxidants (Basel, Switzerland) · 2020Review
- Vitamin C Deficiency and the Risk of Osteoporosis in Patients with an Inflammatory Bowel Disease.Nutrients · 2020Review
- On the effect of vitamin C intake on human health: How to (mis)interprete the clinical evidence.Redox biology · 2020Review
- Vitamin C, Aging and Alzheimer's Disease.Nutrients · 2017Review
- Purple grape juice supplementation in smokers and antioxidant status according to different types of GST polymorphisms.Journal of clinical biochemistry and nutrition · 2015Article
- Human genetic variation influences vitamin C homeostasis by altering vitamin C transport and antioxidant enzyme function.Annual review of nutrition · 2013Review
- A randomized trial of genetic information for personalized nutrition.Genes & nutrition · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeGlutathione S-transferases (GSTs) are intimately involved in combating oxidative stress and in detoxifying xenobiotics. Our objective was to examine possible interactions between polymorphisms in GST genes and plasma vitamin C, tocopherols and carotenoids in 149 reference subjects and 239 subjects occupationally exposed to mineral fibres (asbestos, rock wool, glass fibre), agents that induce oxidative stress.
methodsDeletion of GSTM1 and GSTT1, and substitution 105Ile/Val in GSTP1 genes were determined by PCR, antioxidants in plasma were measured by HPLC.
resultsTocopherols and carotenoids were affected by age, sex, smoking, occupational exposure to fibres, but not by GST polymorphisms. Vitamin C level was influenced by sex, smoking and occupational exposure. Subjects with deletion of GST had lower vitamin C levels compared with subjects carrying the functional gene variant. Vitamin C levels varied according to GSTM1 polymorphism in the whole group (p < 0.05), in all reference subjects (p < 0.05), in the asbestos factory reference group (p < 0.05), and according to GSTT1 polymorphism in reference group of the rock wool plant (p < 0.05). Vitamin C levels were approximately 20% lower in subjects with both functionally deficient genes in the whole group (p < 0.01) and in all non-exposed subjects (p < 0.05).
conclusionsThe correspondence of lower vitamin C levels with non-functional GST isoenzymes may indicate a causal connection between two antioxidant defence pathways, also the underlying mechanism is not yet clear. It seems that supplementation by natural antioxidants is particularly important for subjects with unfavourable genetic makeup and in those exposed to oxidative stress.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.