ArticlePloS one2010
The contributions of interlocking loops and extensive nonlinearity to the properties of circadian clock models.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Comprehensive mapping of abiotic stress inputs into the soybean circadian clock.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Deciphering the Dynamics of Interlocked Feedback Loops in a Model of the Mammalian Circadian Clock.Biophysical journal · 2018Article
- Modeling the interactions of sense and antisense Period transcripts in the mammalian circadian clock network.PLoS computational biology · 2018Article
- Systems Biology-Derived Discoveries of Intrinsic Clocks.Frontiers in neurology · 2017Review
- Elements of biological oscillations in time and space.Nature structural & molecular biology · 2016Article
- Using sign patterns to detect the possibility of periodicity in biological systems.Journal of mathematical biology · 2016Article
- Network representations and methods for the analysis of chemical and biochemical pathways.Molecular bioSystems · 2013Review
- The Goodwin model: behind the Hill function.PloS one · 2013Article
- Model Misinterpretation within Biology: Phenotypes, Statistics, Networks, and Inference.Frontiers in plant science · 2012Article
- Effective models of periodically driven networks.Biophysical journal · 2011Article
- Efficient characterization of high-dimensional parameter spaces for systems biology.BMC systems biology · 2011Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
backgroundSensitivity and robustness are essential properties of circadian clock systems, enabling them to respond to the environment but resist noisy variations. These properties should be recapitulated in computational models of the circadian clock. Highly nonlinear kinetics and multiple loops are often incorporated into models to match experimental time-series data, but these also impact on model properties for clock models. METHODOLOGY/PRINCIPAL
findingsHere, we study the consequences of complicated structure and nonlinearity using simple Goodwin-type oscillators and the complex Arabidopsis circadian clock models. Sensitivity analysis of the simple oscillators implies that an interlocked multi-loop structure reinforces sensitivity/robustness properties, enhancing the response to external and internal variations. Furthermore, we found that reducing the degree of nonlinearity could sometimes enhance the robustness of models, implying that ad hoc incorporation of nonlinearity could be detrimental to a model's perceived credibility.
conclusionThe correct multi-loop structure and degree of nonlinearity are therefore critical in contributing to the desired properties of a model as well as its capacity to match experimental data.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.