ArticleCellular and molecular bioengineering2008
Model for Protein Concentration Gradients in the Cytoplasm.
Article in Cellular and molecular bioengineering, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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Who cites it
37 citing papers in PubMed.
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- Walking the Tightrope: Balancing Opposing Cooperativities as an Operating Principle in Dynein Assembly.bioRxiv : the preprint server for biology · 2026Article
- Nuclear Mechanotransduction Across the Metastatic Cascade: Decoding Spatiotemporal Heterogeneity in Cancer Dissemination.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- From embryos to condensates: A developmental biologist's journey.Journal of molecular biology · 2025Article
- Internal feedback circuits among MEX-5, MEX-6, and PLK-1 maintain faithful patterning in theProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Cellular and Molecular Bioengineering: At the Nexus with the Next Editor-in-Chief.Cellular and molecular bioengineering · 2024Article
- Long-range formation of the Bicoid gradient requires multiple dynamic modes that spatially vary across the embryo.Development (Cambridge, England) · 2024Article
- The architecture of redox microdomains: Cascading gradients and peroxiredoxins' redox-oligomeric coupling integrate redox signaling and antioxidant protection.Redox biology · 2024Article
- Nernst-Planck-Gaussian finite element modelling of CaFrontiers in physiology · 2024Article
- Is there a localized role for translational quality control?RNA (New York, N.Y.) · 2023Article
- Anterior-posterior pattern formation in ciliates.The Journal of eukaryotic microbiology · 2022Review
- Modeling protein dynamics inProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Mechanisms of Viscous Media Effects on Elementary Steps of Bacterial Bioluminescent Reaction.International journal of molecular sciences · 2021Article
- Persistent growth of microtubules at low density.Molecular biology of the cell · 2021Article
- Quantifying the roles of space and stochasticity in computer simulations for cell biology and cellular biochemistry.Molecular biology of the cell · 2021Article
- A Disorder-to-Order Transition Mediates RNA Binding of the Caenorhabditis elegans Protein MEX-5.Biophysical journal · 2020Article
- Spatial regulation of the polarity kinase PAR-1 by parallel inhibitory mechanisms.Development (Cambridge, England) · 2019Article
- Single-molecule study reveals the frenetic lives of proteins in gradients.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Rapid diffusion-state switching underlies stable cytoplasmic gradients in theProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Polo-like Kinase Couples Cytoplasmic Protein Gradients in the C. elegans Zygote.Current biology : CB · 2018Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Intracellular protein concentration gradients are generally thought to be unsustainable at steady-state due to diffusion. Here we show how protein concentration gradients can theoretically be sustained indefinitely through a relatively simple mechanism that couples diffusion to a spatially segregated kinase-phosphatase system. Although it is appreciated that such systems can theoretically give rise to phosphostate gradients, it has been assumed that they do not give rise to gradients in the total protein concentration. Here we show that this assumption does not hold if the two forms of protein have different diffusion coefficients. If, for example, the phosphorylated state binds selectively to a second larger protein or protein complex then a steady state gradient in total protein concentration will be created. We illustrate the principle with an analytical solution to the diffusion-reaction problem and by stochastic individual-based simulations using the Smoldyn program. We argue that protein gradients created in this way need to be considered in experiments using fluorescent probes and could in principle encode spatial information in the cytoplasm.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.