ArticleCellular and molecular bioengineering2009
Characterization of the Concentration-Dependence of Solute Diffusivity and Partitioning in a Model Dextran-Agarose Transport System.
Article in Cellular and molecular bioengineering, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- A latent TGF-β conjugated scaffold improves neocartilage development.Acta biomaterialia · 2026Article
- Modifying Large Molecule Release from Hydrogels Using Microcapillary Channels Patterned with Microfibrous Templates.Polymers for advanced technologies · 2025Article
- Experimental Measurement and Mathematical Quantification of Fixed-Charged Density in Rat and Pig Brain Tissue.Annals of biomedical engineering · 2025Article
- A major functional role of synovial fluid is to reduce the rate of cartilage fatigue failure under cyclical compressive loading.Osteoarthritis and cartilage · 2025Article
- Cell mediated reactions create TGF-β delivery limitations in engineered cartilage.Acta biomaterialia · 2024Article
- Single Hydrogel Particle Mechanics and Dynamics Studied by Combining Capillary Micromechanics with Osmotic Compression.Gels (Basel, Switzerland) · 2023Article
- In-Silico Modelling of Transdermal Delivery of Macromolecule Drugs Assisted by a Skin Stretching Hypobaric Device.Pharmaceutical research · 2023Article
- Particle fraction is a bioactive cue in granular scaffolds.Acta biomaterialia · 2022Article
- A Microfluidic Eye Facsimile System to Examine the Migration of Stem-like Cells.Micromachines · 2022Article
- Blood vessel-on-a-chip examines the biomechanics of microvasculature.Soft matter · 2021Article
- A millisecond passive micromixer with low flow rate, low sample consumption and easy fabrication.Scientific reports · 2021Article
- Direct Osmotic Pressure Measurements in Articular Cartilage Demonstrate Nonideal and Concentration-Dependent Phenomena.Journal of biomechanical engineering · 2021Article
- A 3-D constitutive model for finite element analyses of agarose with a range of gel concentrations.Journal of the mechanical behavior of biomedical materials · 2021Article
- A Macroscopic Diffusion-Based Gradient Generator to Establish Concentration Gradients of Soluble Molecules Within Hydrogel Scaffolds for Cell Culture.Frontiers in chemistry · 2019Article
- Human chondrocyte migration behaviour to guide the development of engineered cartilage.Journal of tissue engineering and regenerative medicine · 2017Article
- Heterogeneous engineered cartilage growth results from gradients of media-supplemented active TGF-β and is ameliorated by the alternative supplementation of latent TGF-β.Biomaterials · 2016Article
- Silk microfiber-reinforced silk hydrogel composites for functional cartilage tissue repair.Acta biomaterialia · 2015Article
- Bath Concentration of Anionic Contrast Agents Does Not Affect Their Diffusion and Distribution in Articular Cartilage In Vitro.Cartilage · 2013Article
- Finite element implementation of mechanochemical phenomena in neutral deformable porous media under finite deformation.Journal of biomechanical engineering · 2011Article
- Validation of theoretical framework explaining active solute uptake in dynamically loaded porous media.Journal of biomechanics · 2010Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
This study reports experimental measurements of solute diffusivity and partition coefficient for various solute concentrations and gel porosities, and proposes novel constitutive relations to describe these observed values. The longer-term aim is to explore the theoretical ramifications of accommodating variations in diffusivity and partition coefficient with solute concentration and tissue porosity, and investigate whether they might suggest novel mechanisms not previously recognized in the field of solute transport in deformable porous media. The study implements a model transport system of agarose hydrogels to investigate the effect of solute concentration and hydrogel porosity on the transport of dextran polysaccharides. The proposed phenomenological constitutive relations are shown to provide better fits of experimental results than prior models proposed in the literature based on the microstructure of the gel. While these constitutive models were developed for the transport of dextran in agarose hydrogels, it is expected that they may also be applied to the transport of similar molecular weight solutes in other porous media. This quantification can assist in the application of biophysical models that describe biological transport in deformable tissues, as well as the cell cytoplasm.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.