Evidence map›Paper›PMID 21152267›Full record

ArticleAdvances in pharmacological sciences2010

A Review of the Pathophysiology and Novel Treatments for Erectile Dysfunction.

George F Lasker, Jason H Maley, Philip J Kadowitz

Open access · goldAbstract read
In one paragraph

Article in Advances in pharmacological sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 71 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Observational
  8. Article
  9. Article
  10. Article
  11. Gas what: NO is not the only answer to sexual function.British journal of pharmacology · 2015
    Review
  12. The sGC activator BAY 60-2770 has potent erectile activity in the rat.American journal of physiology. Heart and circulatory physiology · 2013
    Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

George F LaskerDepartment of Pharmacology, Tulane University School of Medicine, 1430 Tulane Avenue, SL83, New Orleans, LA 70112-2699, USA.
Jason H Maley
Philip J Kadowitz
Tulane University · US

Funding

VISUAL AND ANALYTICAL TOOLS FOR CLUSTER ANALYSISP20RR016456 · NCRR · LOUISIANA STATE UNIV A&M COL BATON ROUGE · PI CHIU, ALAN WING LUN · 2001 to 2011
$28.7M
Role of metabolism in toxicity of inhaled 1,3 butadieneS11ES010018 · NIEHS · SOUTHERN UNIV A&M COL BATON ROUGE · PI MUGANDA, PERPETUA M · 1999 to 2003
$3.8M
CARDIOPULMONARY SURGERY RESEARCHR01HL062000 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI KADOWITZ, PHILIP J · 2000 to 2008
$2.5M
Stem Cell Therapy for Pulmonary HypertensionR01HL077421 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI KADOWITZ, PHILIP J · 2005 to 2008
$1.9M
NCRR NIH HHS P20 RR016456NHLBI NIH HHS R01 HL062000NHLBI NIH HHS R01 HL077421NIEHS NIH HHS S11 ES010018
6 · The paper itself

Abstract

Erectile dysfunction (ED) affects up to 50% of men between the ages of 40 and 70. Treatment with PDE-5 inhibitors is effective in the majority of men with ED. However, PDE-5 inhibitors are not effective when levels of nitric oxide (NO), the principle mediator of erection, are low. The pharmacologic actions of three new potential treatments for ED are discussed in this paper: (1) sGC stimulators/activators, (2) Rho-kinase inhibitors, and (3) sodium nitrite.

Identifiers

PMID21152267
PMCPMC2997760
OpenAlexW1976501995

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.