ArticleJournal of the Korean Society of Coloproctology2010
Risk Factors for the Development of Clostridium difficile-associated Colitis after Colorectal Cancer Surgery.
Article in Journal of the Korean Society of Coloproctology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Clostridium difficile infection after stoma reversal surgery: a systematic review and meta-analysis of the literature.International journal of colorectal disease · 2024Pooled it
- Mechanical bowel preparation and antibiotics in elective colorectal surgery: network meta-analysis.BJS open · 2023Pooled it
- Clinical Characteristics and Outcomes Associated with Clostridium Difficile Infection among Hospitalized Colorectal Cancer Patients Receiving Chemotherapy: a Nationwide Retrospective Analysis.Journal of gastrointestinal cancer · 2026Article
- C. difficile Infection in Colorectal Cancer: Risk Determinants, Outcomes, and Evolving Management Approaches.Journal of gastrointestinal cancer · 2025Review
- Risk factors and outcomes of Clostridioides difficile infection in patients with colorectal cancer: critical perspective in management.Gut pathogens · 2025Review
- Mechanical and oral antibiotics bowel preparation for elective rectal cancer surgery: A propensity score matching analysis using a nationwide inpatient database in Japan.Annals of gastroenterological surgery · 2023Article
- Article
- SAELGMDA: Identifying human microbe-disease associations based on sparse autoencoder and LightGBM.Frontiers in microbiology · 2023Article
- MNNMDA: Predicting human microbe-disease association via a method to minimize matrix nuclear norm.Computational and structural biotechnology journal · 2023Article
- Review
- Oral antibiotics and a low-residue diet reduce the incidence of anastomotic leakage after left-sided colorectal surgery: a retrospective cohort study.Langenbeck's archives of surgery · 2022Article
- To study the contributing factors and outcomes of Clostridioides difficile infection in patients with solid tumors.Heliyon · 2021Article
- Utilization of combination bowel preparation (CBP) is protective against the development of post-operative Clostridium difficile infection (CDI), decreases septic complications, and provides a survival benefit.Surgical endoscopy · 2021Article
- Intestinal Microbiota in Colorectal Cancer Surgery.Cancers · 2020Review
- A comprehensive analysis of the microbiota composition and gene expression in colorectal cancer.BMC microbiology · 2020Article
- Long-Term Antibiotic Prophylaxis in Urology and High Incidence ofMicroorganisms · 2020Article
- The use of oral antibiotics and mechanical bowel preparation in elective colorectal resection for the reduction of surgical site infection.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2020Article
- Gastrointestinal cancers: the role of microbiota in carcinogenesis and the role of probiotics and microbiota in anti-cancer therapy efficacy.Central-European journal of immunology · 2020Review
- Article
- Novel human microbe-disease association prediction using network consistency projection.BMC bioinformatics · 2017Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeClostridium difficile (C. difficile)-associated colitis, a known complication of colon and rectal surgery, can increase perioperative morbidity and mortality, leading to increased hospital stay and costs. Several contributing factors, including advanced age, mechanical bowel preparation, and antibiotics, have been implicated in this condition. The purpose of this study was to determine the clinical features of and factors responsible for C. difficile-associated colitis after colorectal cancer surgery.
methodsThe medical records of patients who had undergone elective resection for colorectal cancer from January 2008 to April 2010 were reviewed. Cases that involved procedures such as transanal excision, stoma creation, or emergency operation were excluded from the analysis.
resultsResection with primary anastomosis was performed in 219 patients with colorectal cancer. The rate of postoperative C. difficile-associated colitis was 6.8% in the entire study population. Preoperative metallic stent insertion (P = 0.017) and aged sixty and older (≥ 60, P = 0.025) were identified as risk factors for postoperative C. difficile-associated colitis. There were no significant differences in variables such as preoperative oral non-absorbable antibiotics, site of operation, operation procedure, and duration of prophylactic antibiotics.
conclusionAmong the potential causative factors of postoperative C. difficile-associated colitis, preoperative metallic stent insertion and aged sixty and older were identified as risk factors on the basis of our data. Strategies to prevent C. difficile infection should be carried out in patients who have undergone preoperative insertion of a metallic stent and are aged sixty and older years.
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