ArticlePLoS genetics2010
LaeA control of velvet family regulatory proteins for light-dependent development and fungal cell-type specificity.
Article in PLoS genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 133 papers.
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Who cites it
133 citing papers in PubMed, 261 citations in OpenAlex.
- Characterization of velvet family proteins regulating fungal development and virulence in the peach shoot blight fungusVirulence · 2026Article
- High-Throughput Analysis Reveals Stable Metabolome ofInternational journal of molecular sciences · 2026Article
- Article
- The VelB IDD promotes selective heterodimer formation of velvet proteins for fungal development.Life science alliance · 2026Article
- Light restores sporulation in Rhizopus microsporus cured of its endosymbionts, unveiling their role in fitness and virulence.The ISME journal · 2026Article
- The Velvet Complex Is Essential for Sclerotia Formation and Virulence inJournal of fungi (Basel, Switzerland) · 2025Article
- Gip1 GPCR regulates two sexual-stage differentiation processes in the ascomycete Fusarium graminearum.Nature communications · 2025Article
- Molecular circuit between Aspergillus nidulans transcription factors MsnA and VelB to coordinate fungal stress and developmental responses.PLoS genetics · 2025Article
- Article
- Review
- A Review of the Biotechnological Potential of Cave Fungi: A Toolbox for the Future.Journal of fungi (Basel, Switzerland) · 2025Review
- Characterization of Blue Light Receptors LreA and LreB inJournal of microbiology and biotechnology · 2025Article
- Genome-wide identification of Solanum tuberosum L. AAAP gene family and its response to abiotic stress.PloS one · 2025Article
- Essential Role of theMycobiology · 2025Article
- The Global Secondary Metabolite RegulatorToxins · 2024Article
- UvVelC is important for conidiation and pathogenicity in the rice false smut pathogenVirulence · 2024Article
- Beyond morphogenesis and secondary metabolism: function of Velvet proteins and LaeA in fungal pathogenesis.Applied and environmental microbiology · 2024Review
- Histone H2B lysine 122 and lysine 130, as the putative targets of Penicillium oxalicum LaeA, play important roles in asexual development, expression of secondary metabolite gene clusters, and extracellular glycoside hydrolase synthesis.World journal of microbiology & biotechnology · 2024Article
- Phylogenomics analysis of velvet regulators in the fungal kingdom.Microbiology spectrum · 2024Article
- A Network of Sporogenesis-Responsive Genes Regulates the Growth, Asexual Sporogenesis, Pathogenesis and Fusaric Acid Production ofJournal of fungi (Basel, Switzerland) · 2023Article
73 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
VeA is the founding member of the velvet superfamily of fungal regulatory proteins. This protein is involved in light response and coordinates sexual reproduction and secondary metabolism in Aspergillus nidulans. In the dark, VeA bridges VelB and LaeA to form the VelB-VeA-LaeA (velvet) complex. The VeA-like protein VelB is another developmental regulator, and LaeA has been known as global regulator of secondary metabolism. In this study, we show that VelB forms a second light-regulated developmental complex together with VosA, another member of the velvet family, which represses asexual development. LaeA plays a key role, not only in secondary metabolism, but also in directing formation of the VelB-VosA and VelB-VeA-LaeA complexes. LaeA controls VeA modification and protein levels and possesses additional developmental functions. The laeA null mutant results in constitutive sexual differentiation, indicating that LaeA plays a pivotal role in inhibiting sexual development in response to light. Moreover, the absence of LaeA results in the formation of significantly smaller fruiting bodies. This is due to the lack of a specific globose cell type (Hülle cells), which nurse the young fruiting body during development. This suggests that LaeA controls Hülle cells. In summary, LaeA plays a dynamic role in fungal morphological and chemical development, and it controls expression, interactions, and modification of the velvet regulators.
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