ArticlePLoS computational biology2010
A systems model for immune cell interactions unravels the mechanism of inflammation in human skin.
Article in PLoS computational biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Mathematical modeling in autoimmune diseases: from theory to clinical application.Frontiers in immunology · 2024Pooled it
- Serum and cerebrospinal fluid immune mediators in children with autistic disorder: a longitudinal study.Molecular autism · 2017Trial
- An in silico approach deciphering the commensal dynamics in the cutaneous milieu.NPJ systems biology and applications · 2025Article
- Diffusive mediator feedbacks control the health-to-disease transition of skin inflammation.PLoS computational biology · 2024Article
- Dynamics of a network mediated by IL-36 and involved in the pathogenesis of psoriasis.Frontiers in network physiology · 2024Article
- Systems biology platform for efficient development and translation of multitargeted therapeutics.Frontiers in systems biology · 2023Article
- The effect of muscle length on post-tetanic potentiation of C57BL/6 and skMLCKJournal of muscle research and cell motility · 2022Article
- Traveling wave of inflammatory response to regulate the expansion or shrinkage of skin erythema.PloS one · 2022Article
- Role of subnetworks mediated by [Formula: see text], IL-23/IL-17 and IL-15 in a network involved in the pathogenesis of psoriasis.Scientific reports · 2021Article
- ImmunoGlobe: enabling systems immunology with a manually curated intercellular immune interaction network.BMC bioinformatics · 2020Article
- The competitive nature of signal transducer and activator of transcription complex formation drives phenotype switching of T cells.Immunology · 2018Article
- Integrating Immunology and Microfluidics for Single Immune Cell Analysis.Frontiers in immunology · 2018Review
- Current knowledge on psoriasis and autoimmune diseases.Psoriasis (Auckland, N.Z.) · 2016Review
- Computational modeling of cytokine signaling in microglia.Molecular bioSystems · 2015Article
- Cytokines in psoriasis.Cytokine · 2015Review
- Cytokine expression provides clues to the pathophysiology of Gulf War illness and myalgic encephalomyelitis.Cytokine · 2015Article
- Regulation of Dendritic Cell Function in Inflammation.Journal of immunology research · 2015Review
- Psoriasis.Cold Spring Harbor perspectives in medicine · 2014Review
- Senescent fibroblasts in melanoma initiation and progression: an integrated theoretical, experimental, and clinical approach.Cancer research · 2013Article
- Risk factor-dependent dynamics of atopic dermatitis: modelling multi-scale regulation of epithelium homeostasis.Interface focus · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
Inflammation is characterized by altered cytokine levels produced by cell populations in a highly interdependent manner. To elucidate the mechanism of an inflammatory reaction, we have developed a mathematical model for immune cell interactions via the specific, dose-dependent cytokine production rates of cell populations. The model describes the criteria required for normal and pathological immune system responses and suggests that alterations in the cytokine production rates can lead to various stable levels which manifest themselves in different disease phenotypes. The model predicts that pairs of interacting immune cell populations can maintain homeostatic and elevated extracellular cytokine concentration levels, enabling them to operate as an immune system switch. The concept described here is developed in the context of psoriasis, an immune-mediated disease, but it can also offer mechanistic insights into other inflammatory pathologies as it explains how interactions between immune cell populations can lead to disease phenotypes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.