Evidence map›Paper›PMID 21151848›Full record

ArticleMRS bulletin2010

Shape and Biomechanical Characteristics of Human Red Blood Cells in Health and Disease.

Monica Diez-Silva, Ming Dao, Jongyoon Han, Chwee-Teck Lim, Subra Suresh

Open access · bronzeAbstract read
In one paragraph

Article in MRS bulletin, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 198 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
198citing papers in PubMed, 1 pooled it
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

198 citing papers in PubMed, 1 synthesis or guideline pooled it, 583 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Photoacoustics · 2026
    Article
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  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Review
  15. Red Blood Cell Membrane Mechanics Using Discrete Exterior Calculus (DEC) and Optimization.International journal for numerical methods in biomedical engineering · 2026
    Article
  16. Article
  17. Article
  18. Article
  19. Observational
  20. Review

138 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Monica Diez-Silva
Ming Dao
Jongyoon Han
Chwee-Teck Lim
Subra Suresh

Funding

Multiscale Modeling and Parallel Simulations of Blood Flow in Cerebral Malaria anR01HL094270 · NHLBI · BROWN UNIVERSITY · PI KARNIADAKIS, GEORGE, SURESH, SUBRA · 2009 to 2011
$1.8M
MSM-Multi-scale Analysis of Cellular Force Transmission and Biochemical ActivatioR01GM076689 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI KAMM, ROGER D. · 2005 to 2007
$871k
NHLBI NIH HHS R01 HL094270NIGMS NIH HHS R01 GM076689
6 · The paper itself

Abstract

The biconcave shape and corresponding deformability of the human red blood cell (RBC) is an essential feature of its biological function. This feature of RBCs can be critically affected by genetic or acquired pathological conditions. In this review, we highlight new dynamic in vitro assays that explore various hereditary blood disorders and parasitic infectious diseases that cause disruption of RBC morphology and mechanics. In particular, recent advances in high-throughput microfluidic devices make it possible to sort/identify healthy and pathological human RBCs with different mechanobiological characteristics.

Identifiers

PMID21151848
PMCPMC2998922
OpenAlexW2131895213

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.