ArticleFrontiers in neuroscience2010
Long-Range GABAergic Connections Distributed throughout the Neocortex and their Possible Function.
Article in Frontiers in neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
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Who cites it
64 citing papers in PubMed, 110 citations in OpenAlex.
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- A primary auditory cortex-anterior cingulate cortex circuit underlying cross-modal visceral pain modulation.Nature communications · 2026Article
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- Presynaptic Trafficking of Glutamate Decarboxylase Isoforms Is Dispensable for Basal GABAergic Neurotransmission.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- A novel image-based neuronal network model framework for understanding visual multistability and neurological disorders.Frontiers in computational neuroscience · 2026Article
- Prefrontal long-range somatostatin inhibitory projections modulate fear expression.Frontiers in cellular neuroscience · 2026Article
- Long-range inhibition from prelimbic to cingulate areas of the medial prefrontal cortex enhances network activity and response execution.Nature communications · 2024Article
- GABAergic dysfunction in postmortem dorsolateral prefrontal cortex: implications for cognitive deficits in schizophrenia and affective disorders.Frontiers in cellular neuroscience · 2024Review
- Paraventricular Hypothalamic Nucleus Upregulates Intraocular Pressure Via Glutamatergic Neurons.Investigative ophthalmology & visual science · 2023Article
- Localization and Diagnostic Specificity of Glutamic Acid Decarboxylase Transcript Alterations in the Dorsolateral Prefrontal Cortex in Schizophrenia.Biological psychiatry · 2023Article
- New insights into binocular rivalry from the reconstruction of evolving percepts using model network dynamics.Frontiers in computational neuroscience · 2023Article
- Prefrontal Interneurons: Populations, Pathways, and Plasticity Supporting Typical and Disordered Cognition in Rodent Models.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Review
- The Distinct Characteristics of Somatostatin Neurons in the Human Brain.Molecular neurobiology · 2022Article
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- Long-Range GABAergic Projections of Cortical Origin in Brain Function.Frontiers in systems neuroscience · 2022Review
- VIP-Expressing GABAergic Neurons: Disinhibitory vs. Inhibitory Motif and Its Role in Communication Across Neocortical Areas.Frontiers in cellular neuroscience · 2022Review
- Development, Diversity, and Death of MGE-Derived Cortical Interneurons.International journal of molecular sciences · 2021Review
- Network-centered homeostasis through inhibition maintains hippocampal spatial map and cortical circuit function.Cell reports · 2021Article
- Contribution of Excitatory and Inhibitory Neuronal Activity to BOLD fMRI.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
4 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Features and functions of long-range GABAergic projection neurons in the developing cerebral cortex have been reported previously, although until now their significance in the adult cerebral cortex has remained uncertain. The septo-hippocampal circuit is one exception - in this system, long-range mature GABAergic projection neurons have been well analyzed and their contribution to the generation of theta-oscillatory behavior in the hippocampus has been documented. To have a clue to the function of the GABAergic projection neurons in the neocortex, we view how the long-range GABAergic projections are integrated in the cortico-cortical, cortico-fugal, and afferent projections in the cerebral cortex. Then, we consider the possibility that the GABAergic projection neurons are involved in the generation, modification, and/or synchronization of oscillations in mature neocortical neuron activity. When markers that identify the GABAergic projection neurons are examined in anatomical and developmental studies, it is clear that neuronal NO synthetase (nNOS)-immunoreactivity can readily identify GABAergic projection neurons. GABAergic projection neurons account for 0.5% of the neocortical GABAergic neurons. To elucidate the role of the GABAergic projection neurons in the neocortex, it will be necessary to clarify the network constructed by nNOS-positive GABAergic projection neurons and their postsynaptic targets. Thus, our long-range goals will be to label and manipulate (including deleting) the GABAergic projection neurons using genetic tools driven by a nNOS promoter. We recognize that this may be a complex endeavor, as most excitatory neurons in the murine neocortex express nNOS transiently. Nevertheless, additional studies characterizing long-range GABAergic projection neurons will have great value to the overall understanding of mature cortical function.
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