ArticleMolecular vision2010
Polymorphisms of IL23R and Fuchs' syndrome in a Chinese Han population.
Article in Molecular vision, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- The association between genetic polymorphisms of the interleukin-23 receptor gene and susceptibility to uveitis: a meta-analysis.BMC ophthalmology · 2017Pooled it
- Genetic of uveitis.International ophthalmology · 2016Review
- Hepatocyte growth factor genetic variations and primary angle-closure glaucoma in the Han Chinese population.PloS one · 2013Article
- IL23R gene confers susceptibility to ankylosing spondylitis concomitant with uveitis in a Han Chinese population.PloS one · 2013Article
- Lack of association of miR-146a and Ets-1 gene polymorphisms with Fuchs uveitis syndrome in Chinese Han patients.Molecular vision · 2012Article
- Complement factor H and interleukin gene polymorphisms in patients with non-infectious intermediate and posterior uveitis.Molecular vision · 2012Article
- CD40 polymorphisms in Han Chinese patients with Fuch uveitis syndrome.Molecular vision · 2011Article
- CFH 184G as a genetic risk marker for anterior uveitis in Chinese females.Molecular vision · 2011Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of the study was to investigate the association of polymorphisms of the interleukin-23 receptor (IL23R) gene with Fuchs' syndrome in a Chinese Han population.
methodsThree single-nucleotide polymorphisms (SNPs), rs7517847, rs11209032 and rs17375018 of IL23R were genotyped in 138 Chinese Han patients with Fuchs' syndrome and 407 healthy controls by using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Data were analyzed by χ(2) analysis.
resultsAll genotype and allele distributions in patients with Fuchs' syndrome and healthy controls were in Hardy-Weinberg equilibrium. The frequency of the rs11209032 AA genotype was significantly increased in patients with Fuchs' syndrome as compared to controls (corrected p [pc]=0.036, OR 1.86, 95%CI 1.21 to 2.86). There were no statistically significant differences between patients and healthy controls concerning the other two tested SNPs (rs17375018 and rs7517847). The haplotypes of the tested SNPs were not different between patients and controls. Additionally, analysis according to gender did not show any influence of sex on the association of IL23R with Fuchs' syndrome.
conclusionsOur results suggested that the rs11209032 AA genotype of the IL23R gene may predispose for Fuchs' syndrome in Chinese patients.
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Identifiers
21151597PMC3000233W1829371653What OpenQuestion holds
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