ArticleInternational journal of molecular sciences2010
Proteomic analysis of whole human saliva detects enhanced expression of interleukin-1 receptor antagonist, thioredoxin and lipocalin-1 in cigarette smokers compared to non-smokers.
Article in International journal of molecular sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Biomarkers Identification in the Microenvironment of Oral Squamous Cell Carcinoma: A Systematic Review of Proteomic Studies.International journal of molecular sciences · 2024Pooled it
- Changes in the Protein Profile of Saliva from People with Obesity Treated with Bariatric Surgery and Physical Exercise.International journal of molecular sciences · 2025Article
- Ectopic pregnancy: search for biomarker in salivary proteome.Scientific reports · 2023Article
- The Influence of (Poly)phenol Intake in Saliva Proteome: Short- and Medium-Term Effects of Apple.Foods (Basel, Switzerland) · 2023Article
- Genomic Analysis of Waterpipe Smoke-Induced Lung Tumor Autophagy and Plasticity.International journal of molecular sciences · 2022Article
- Tear Lipocalin and Lipocalin-Interacting Membrane Receptor.Frontiers in physiology · 2021Article
- Changes in salivary proteome before and after cigarette smoking in smokers compared to sham smoking in nonsmokers: A pilot study.Tobacco induced diseases · 2021Article
- Salivary Biomarkers in Lung Cancer.Mediators of inflammation · 2021Review
- Lipocalin-1 Expression as a Prognosticator Marker of Survival in Breast Cancer Patients.Breast care (Basel, Switzerland) · 2020Article
- Changes in Salivary Proteome in Response to Bread Odour.Nutrients · 2020Article
- Molecular alterations associated with chronic exposure to cigarette smoke and chewing tobacco in normal oral keratinocytes.Cancer biology & therapy · 2018Article
- Can Saliva Proteins Be Used to Predict the Onset of Acute Myocardial Infarction among High-Risk Patients?International journal of medical sciences · 2015Review
- Increased serum levels of lipocalin-1 and -2 in patients with stable chronic obstructive pulmonary disease.International journal of chronic obstructive pulmonary disease · 2014Observational
- Rifampicin protects PC12 cells from rotenone-induced cytotoxicity by activating GRP78 via PERK-eIF2α-ATF4 pathway.PloS one · 2014Article
- Quantitative estimation of sodium, potassium and total protein in saliva of diabetic smokers and nonsmokers: A novel study.Journal of natural science, biology, and medicine · 2013Article
- Identification of oxidative stress related proteins as biomarkers for lung cancer and chronic obstructive pulmonary disease in bronchoalveolar lavage.International journal of molecular sciences · 2013Article
- Development of transcriptomic biomarker signature in human saliva to detect lung cancer.Cellular and molecular life sciences : CMLS · 2012Article
- Proteomic analysis of human saliva from lung cancer patients using two-dimensional difference gel electrophoresis and mass spectrometry.Molecular & cellular proteomics : MCP · 2012Article
- Salivary proteins associated with periodontitis in patients with Type 2 diabetes mellitus.International journal of molecular sciences · 2012Article
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Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A gel-based proteomics approach was used to screen for proteins of differential abundance between the saliva of smokers and those who had never smoked. Subjecting precipitated proteins from whole human saliva of healthy non-smokers to two-dimensional electrophoresis (2-DE) generated typical profiles comprising more than 50 proteins. While 35 of the proteins were previously established by other researchers, an additional 22 proteins were detected in the 2-DE saliva protein profiles generated in the present study. When the 2-DE profiles were compared to those obtained from subjects considered to be heavy cigarette smokers, three saliva proteins, including interleukin-1 receptor antagonist, thioredoxin and lipocalin-1, showed significant enhanced expression. The distribution patterns of lipocalin-1 isoforms were also different between cigarette smokers and non-smokers. The three saliva proteins have good potential to be used as biomarkers for the adverse effects of smoking and the risk for inflammatory and chronic diseases that are associated with it.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.