Evidence map›Paper›PMID 21151389›Full record

ArticleInternational journal of clinical and experimental pathology2010

Selective central nervous system tropism of primary central nervous system lymphoma.

Liuyan Jiang, Laura A Marlow, Simon J Cooper, Christina V Roemeling, David M Menke, John A Copland, Han W Tun

Abstract readCase Reports
In one paragraph

Article in International journal of clinical and experimental pathology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Liuyan JiangDepartment of Hematology/Oncology, Mayo Clinic, Jacksonville, Florida 32224, USA
Laura A Marlow
Simon J Cooper
Christina V Roemeling
David M Menke
John A Copland
Han W Tun

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Primary Central nervous system lymphoma (PCNSL) is most frequently a diffuse large B cell lymphoma (DLBCL), which is confined to the Central nervous system (CNS). We performed an experiment in which lymphoma cells from a PCNSL patient were implanted subcutaneously in an athymic mouse. The lymphoma cells were shown to home to the CNS with histologic evaluations of the brain showing multiple large B cells in blood vessels consistent with intravascular large B cell lymphoma (IVL). We did not find any evidence of lymphoma at the site of implantation or other locations. The findings are consistent with highly selective tropism of PCNSLforthe CNS and its vasculature.

Indexed as

AdultAnimalsBiomarkers, TumorBrainBrain NeoplasmsCell MovementCentral Nervous System NeoplasmsFatal OutcomeFemaleHumansLymphocytesLymphoma, Large B-Cell, DiffuseMiceMice, NudeNeoplasm InvasivenessNeoplasm TransplantationBiomarkers, TumorOsteopontincentral nervous systemLymphomatropism

Identifiers

PMID21151389
PMCPMC2993226

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.