ArticleFrontiers in neuroscience2010
Anti-malaria drug mefloquine induces motor learning deficits in humans.
Article in Frontiers in neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 29 citations in OpenAlex.
- Electrical Synapses Contribute to Sleep-Dependent Declarative Memory Retention.The European journal of neuroscience · 2026Article
- Electrical coupling controls dimensionality and chaotic firing of inferior olive neurons.PLoS computational biology · 2020Article
- Electrical synapses in mammalian CNS: Past eras, present focus and future directions.Biochimica et biophysica acta. Biomembranes · 2018Review
- A novel eyelid motion monitor.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2017Article
- An Internal Focus Leads to Longer Quiet Eye Durations in Novice Dart Players.Frontiers in psychology · 2016Article
- A small-fish model for behavioral-toxicological screening of new antimalarial drugs: a comparison between erythro- and threo-mefloquine.BMC research notes · 2015Article
- Rational Risk-Benefit Decision-Making in the Setting of Military Mefloquine Policy.Journal of parasitology research · 2015Review
- Complex Membrane Channel Blockade: A Unifying Hypothesis for the Prodromal and Acute Neuropsychiatric Sequelae Resulting from Exposure to the Antimalarial Drug Mefloquine.Journal of parasitology research · 2015Review
- Behavioral correlates of complex spike synchrony in cerebellar microzones.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Epilepsy triggered by mefloquine in an adult traveler to Uganda.World journal of clinical cases · 2014Article
- Role of the olivo-cerebellar complex in motor learning and control.Frontiers in neural circuits · 2013Review
- The anti-malarial drug Mefloquine disrupts central autonomic and respiratory control in the working heart brainstem preparation of the rat.Journal of biomedical science · 2012Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mefloquine (a marketed anti-malaria drug) prophylaxis has a high risk of causing adverse events. Interestingly, animal studies have shown that mefloquine imposes a major deficit in motor learning skills by affecting the connexin 36 gap junctions of the inferior olive. We were therefore interested in assessing whether mefloquine might induce similar effects in humans. The main aim of this study was to investigate the effect of mefloquine on olivary-related motor performance and motor learning tasks in humans. We subjected nine participants to voluntary motor timing (dart throwing task), perceptual timing (rhythm perceptual task) and reflex timing tasks (eye-blink task) before and 24 h after the intake of mefloquine. The influence of mefloquine on motor learning was assessed by subjecting participants with and without mefloquine intake (controls: n = 11 vs mefloquine: n = 8) to an eye-blink conditioning task. Voluntary motor performance, perceptual timing, and reflex blinking were not affected by mefloquine use. However, the influence of mefloquine on motor learning was substantial; both learning speed as well as learning capacity was impaired by mefloquine use. Our data suggest that mefloquine disturbs motor learning skills. This adverse effect can have clinical as well as social clinical implications for mefloquine users. Therefore, this side-effect of mefloquine should be further investigated and recognized by clinicians.
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