Evidence map›Paper›PMID 21151110›Full record

ReviewNature nanotechnology2011

Nanotechnological strategies for engineering complex tissues.

Tal Dvir, Brian P Timko, Daniel S Kohane, Robert Langer

Abstract readReview
In one paragraph

Review in Nature nanotechnology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 359 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
359citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

359 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  15. Novel Electroactive Therapeutic Platforms for Cardiac Arrhythmia Management.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
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299 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Tal DvirDepartment of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Brian P Timko
Daniel S Kohane
Robert Langer

Funding

PHOTOPOLYMERIZATION FOR NONINVASIVE CARTILAGE TISSUER01DE013023 · NIDCR · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI LANGER, ROBERT SAMUEL · 1998 to 2019
$6.8M
Microchip Drug Delivery SystemR01EB006365 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI LANGER, ROBERT SAMUEL · 2007 to 2011
$5.8M
Prolonged Duration Local AnesthesiaR01GM073626 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI KOHANE, DANIEL S · 2006 to 2018
$4.7M
High-Throughput Craniofacial tissue engineeringR01DE016516 · NIDCR · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI LANGER, ROBERT SAMUEL · 2005 to 2014
$3.8M
A Photo-triggered on-demand drug delivery system for chronic painF32GM096546 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI TIMKO, BRIAN PAUL · 2011 to 2012
$101k
NIBIB NIH HHS EB006365NIBIB NIH HHS R01 EB006365NIDCR NIH HHS DE016516NIDCR NIH HHS DE13023NIDCR NIH HHS R01 DE013023NIDCR NIH HHS R01 DE016516NIGMS NIH HHS R01 GM073626NIGMS NIH HHS R01GM073626
6 · The paper itself

Abstract

Tissue engineering aims at developing functional substitutes for damaged tissues and organs. Before transplantation, cells are generally seeded on biomaterial scaffolds that recapitulate the extracellular matrix and provide cells with information that is important for tissue development. Here we review the nanocomposite nature of the extracellular matrix, describe the design considerations for different tissues and discuss the impact of nanostructures on the properties of scaffolds and their uses in monitoring the behaviour of engineered tissues. We also examine the different nanodevices used to trigger certain processes for tissue development, and offer our view on the principal challenges and prospects of applying nanotechnology in tissue engineering.

Indexed as

NanomedicineBiocompatible MaterialsCells, CulturedExtracellular MatrixNanocompositesTissue EngineeringTissue ScaffoldsBiocompatible Materials

Identifiers

PMID21151110
PMCPMC4059057

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.