ArticleCell death and differentiation2011
Caspase-3-mediated degradation of condensin Cap-H regulates mitotic cell death.
Article in Cell death and differentiation, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Non-structural maintenance of chromosome condensin I complex subunit H knockdown suppresses malignant progression of esophageal squamous cell carcinoma via the Wnt/β-catenin signaling pathway.Journal of gastrointestinal oncology · 2026Article
- NCAPH is a prognostic biomarker and associated with immune infiltrates in lung adenocarcinoma.Scientific reports · 2022Article
- Superresolution Microscopy for Visualization of Physical Contacts Between Chromosomes at Nanoscale Resolution.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Identification of NCAPH as a biomarker for prognosis of breast cancer.Molecular biology reports · 2020Article
- Large domains of heterochromatin direct the formation of short mitotic chromosome loops.eLife · 2020Article
- Elevated mRNA Expression Levels of NCAPG are Associated with Poor Prognosis in Ovarian Cancer.Cancer management and research · 2020Article
- Condensin controls mitotic chromosome stiffness and stability without forming a structurally contiguous scaffold.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2018Article
- Cell death response to anti-mitotic drug treatment in cell culture, mouse tumor model and the clinic.Endocrine-related cancer · 2017Review
- Interactome disassembly during apoptosis occurs independent of caspase cleavage.Molecular systems biology · 2017Article
- Article
- Exploring Mouse Protein Function via Multiple Approaches.PloS one · 2016Article
- Shaping mitotic chromosomes: From classical concepts to molecular mechanisms.BioEssays : news and reviews in molecular, cellular and developmental biology · 2015Review
- Nanoformulated cell-penetrating survivin mutant and its dual actions.International journal of nanomedicine · 2014Article
- Post-slippage multinucleation renders cytotoxic variation in anti-mitotic drugs that target the microtubules or mitotic spindle.Cell cycle (Georgetown, Tex.) · 2014Article
- A SILAC-based approach identifies substrates of caspase-dependent cleavage upon TRAIL-induced apoptosis.Molecular & cellular proteomics : MCP · 2013Article
- Article
- Linking abnormal mitosis to the acquisition of DNA damage.The Journal of cell biology · 2012Review
- Mitosis-targeted anti-cancer therapies: where they stand.Cell death & disease · 2012Review
- Condensins: universal organizers of chromosomes with diverse functions.Genes & development · 2012Review
- Prolonged mitotic arrest triggers partial activation of apoptosis, resulting in DNA damage and p53 induction.Molecular biology of the cell · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mitotic death is a major form of cell death in cancer cells that have been treated with chemotherapeutic drugs. However, the mechanisms underlying this form of cell death is poorly understood. Here, we report that the loss of chromosome integrity is an important determinant of mitotic death. During prolonged mitotic arrest, caspase-3 is activated and it cleaves Cap-H, a subunit of condensin I. The depletion of Cap-H results in the loss of condensin I complex at the chromosomes, thus affecting the integrity of the chromosomes. Consequently, DNA fragmentation by caspase-activated DNase is facilitated, thus driving the cell towards mitotic death. By expressing a caspase-resistant form of Cap-H, mitotic death is abrogated and the cells are able to reenter interphase after a long mitotic delay. Taken together, we provide new insights into the molecular events that occur during mitotic death.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.