ArticleJournal of perinatology : official journal of the California Perinatal Association2011
Agreement of umbilical cord drug and cotinine levels with maternal self-report of drug use and smoking during pregnancy.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic Review: Polysubstance Prevalence Estimates Reported during Pregnancy, US, 2009-2020.Maternal and child health journal · 2023Pooled it
- Protective placental inflammatory and oxidative stress responses are attenuated in the context of twin pregnancy and chorioamnionitis in assisted reproduction.Journal of assisted reproduction and genetics · 2022Article
- Detection and quantitation of non-steroidal anti-inflammatory drug use close to the time of birth using umbilical cord tissue.Toxicology reports · 2020Article
- Article
- Detection of opioids in umbilical cord lysates: an antibody-based rapid screening approach.Toxicology mechanisms and methods · 2019Article
- Screening Pregnant Women and Their Neonates for Illicit Drug Use: Consideration of the Integrated Technical, Medical, Ethical, Legal, and Social Issues.Frontiers in pharmacology · 2018Review
- ATP-binding cassette proteins BCRP, MRP1 and P-gp expression and localization in the human umbilical cord.Xenobiotica; the fate of foreign compounds in biological systems · 2016Article
- Study protocol: Asking QUestions about Alcohol in pregnancy (AQUA): a longitudinal cohort study of fetal effects of low to moderate alcohol exposure.BMC pregnancy and childbirth · 2014Article
- Translational toxicology: a developmental focus for integrated research strategies.BMC pharmacology & toxicology · 2013Article
- Cotinine in human placenta predicts induction of gene expression in fetal tissues.Drug metabolism and disposition: the biological fate of chemicals · 2013Article
- Effect of secondhand smoke on asthma control among black and Latino children.The Journal of allergy and clinical immunology · 2012Article
- Umbilical cord blood cotinine and smoking during pregnancy.Journal of perinatology : official journal of the California Perinatal Association · 2012Article
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5 authors.
Funding
Abstract
objectiveWe undertook this study to assess the agreement between fetal umbilical cord drug levels and maternal self-report. STUDY
designCord samples were collected from 103 placentas after delivery as a subproject of the larger Pacific Research Center for Early Human Development (PRCEHD) study. These cord samples were then processed to obtain cord lysates and enzyme-linked immunosorbent assay (ELISA) performed for cotinine and illicit drugs. Levels of each of these substances were compared with clinical information.
resultWe found fair agreement between self-reported smoking and cotinine levels (κ = 0.26 (0.07 to 0.5)) as well as slight agreement with current drug use and positive drug levels (κ = 0.19 (-0.05 to 0.4)). Compared with maternal self-report, sensitivity of cotinine levels was 27% and specificity was 98%. Sensitivity of positive cord illicit drug levels was 32% and specificity was 85%.
conclusionUmbilical cords provide another independent measure of maternal drug use and are readily available. To our knowledge, this is the first study to measure cotinine levels in the umbilical cord tissue.
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