ReviewNature reviews. Cancer2011
Cell lineage and cell death: Caenorhabditis elegans and cancer research.
Review in Nature reviews. Cancer, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- AI-Driven Combination Therapy for Counteracting Dysregulated Genes in Lung Adenocarcinoma: Contribution-Aware Metaheuristic for Drug Repurposing.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Methanol Extracts fromMolecules (Basel, Switzerland) · 2023Article
- Modeling neoplastic disease with spheroids and organoids.Journal of hematology & oncology · 2020Review
- Dissecting cell-type-specific roles of androgen receptor in prostate homeostasis and regeneration through lineage tracing.Nature communications · 2017Article
- Article
- Enrichment of druggable conformations from apo protein structures using cosolvent-accelerated molecular dynamics.Biology · 2015Article
- Asymmetric neuroblast divisions producing apoptotic cells require the cytohesin GRP-1 in Caenorhabditis elegans.Genetics · 2014Article
- LIN-3/EGF promotes the programmed cell death of specific cells in Caenorhabditis elegans by transcriptional activation of the pro-apoptotic gene egl-1.PLoS genetics · 2014Article
- The DEP domain-containing protein TOE-2 promotes apoptosis in the Q lineage of C. elegans through two distinct mechanisms.Development (Cambridge, England) · 2014Article
- Shaping organisms with apoptosis.Cell death and differentiation · 2013Review
- Article
- Basic Caenorhabditis elegans methods: synchronization and observation.Journal of visualized experiments : JoVE · 2012Article
- A predictable worm: application of Caenorhabditis elegans for mechanistic investigation of movement disorders.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2012Review
- Reduction of mitoferrin results in abnormal development and extended lifespan in Caenorhabditis elegans.PloS one · 2012Article
- Chromatin remodeling system, cancer stem-like attractors, and cellular reprogramming.Cellular and molecular life sciences : CMLS · 2011Article
- High glucose diets shorten lifespan of Caenorhabditis elegans via ectopic apoptosis induction.Nutrition research and practice · 2011Article
Corrections and comments
- Erratum issued
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cancer is a complex disease in which cells have circumvented normal restraints on tissue growth and have acquired complex abnormalities in their genomes, posing a considerable challenge to identifying the pathways and mechanisms that drive fundamental aspects of the malignant phenotype. Genetic analyses of the normal development of the nematode Caenorhabditis elegans have revealed evolutionarily conserved mechanisms through which individual cells establish their fates, and how they make and execute the decision to survive or undergo programmed cell death. The pathways identified through these studies have mammalian counterparts that are co-opted by malignant cells. Effective cancer drugs now target some of these pathways, and more are likely to be discovered.
Indexed as
Identifiers
21150934What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.