ArticleMolecules (Basel, Switzerland)2010
Antidiabetic properties and mechanism of action of Gynura procumbens water extract in streptozotocin-induced diabetic rats.
Article in Molecules (Basel, Switzerland), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 140 citations in OpenAlex.
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- Pharmacological Overview of Bioactive Natural Products fromPlants (Basel, Switzerland) · 2025Review
- Modes of action of traditional Chinese medicine for diabetic infertility: from molecular pathways to clinical evidence.American journal of clinical and experimental immunology · 2025Review
- Antidiabetic potential ofFrontiers in pharmacology · 2025Review
- Exploring Folklore Ecuadorian Medicinal Plants and Their Bioactive Components Focusing on Antidiabetic Potential: An Overview.Plants (Basel, Switzerland) · 2024Review
- Protein hydrolysates ofHeliyon · 2024Article
- Effects ofFrontiers in veterinary science · 2024Article
- Potentials of Gynura procumbens to modulate chronic stress and immunological responses in Oreochromis niloticus.PloS one · 2023Article
- Enhancement of nutraceutical and anti-diabetic potential of fenugreek (Trigonella foenum-graecum). Sprouts with natural elicitors.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2023Article
- Naringin Ameliorates Skeletal Muscle Atrophy and Improves Insulin Resistance in High-Fat-Diet-Induced Insulin Resistance in Obese Rats.Nutrients · 2022Article
- In Vivo and In Silico Assessment of Diabetes Ameliorating Potentiality and Safety Profile ofEvidence-based complementary and alternative medicine : eCAM · 2022Article
- Based on Plasma Metabonomics and Network Pharmacology Exploring the Therapeutic Mechanism ofFrontiers in pharmacology · 2021Article
- Antidiabetic activity of corn steep liquor extract ofJournal of traditional and complementary medicine · 2020Article
- Antioxidant Effects and Mechanisms of Medicinal Plants and Their Bioactive Compounds for the Prevention and Treatment of Type 2 Diabetes: An Updated Review.Oxidative medicine and cellular longevity · 2020Review
- UHPLC-ESI-Orbitrap-MS Analysis of Biologically Active Extracts fromEvidence-based complementary and alternative medicine : eCAM · 2020Article
- Comparison of chloroplast genomes of Gynura species: sequence variation, genome rearrangement and divergence studies.BMC genomics · 2019Article
- Histological and biochemical effects of Cinnamomum cassia nanoparticles in kidneys of diabetic Sprague-Dawley rats.Bosnian journal of basic medical sciences · 2019Article
- Antidiabetic activity, glucose uptake stimulation and α-glucosidase inhibitory effect of Chrysophyllum cainito L. stem bark extract.BMC complementary and alternative medicine · 2018Article
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4 authors at 1 institution in 1 country.
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Abstract
Gynura procumbens (Lour.) Merr (family Compositae) is cultivated in Southeast Asia, especially Indonesia, Malaysia and Thailand, for medicinal purposes. This study evaluated the in vivo hypoglycemic properties of the water extract of G. procumbens following 14 days of treatment and in vitro in RIN-5F cells. Glucose absorption from the intestines and its glucose uptake in abdominal skeletal muscle were assessed. The antidiabetic effect of water extract of G. procumbens leaves was investigated in streptozotocin-induced diabetic rats. The intraperitoneal glucose tolerance test (IPGTT) was performed in diabetic rats treated with G. procumbens water extract for 14 days. In the IPGTT, blood was collected for insulin and blood glucose measurement. After the IPGTT, the pancreases were collected for immunohistochemical study of β-cells of the islets of Langerhans. The possible antidiabetic mechanisms of G. procumbens were assessed through in vitro RIN-5F cell study, intestinal glucose absorption and glucose uptake by muscle. The results showed that G. procumbens significantly decreased blood glucose levels after 14 days of treatment and improved outcome of the IPGTT. However, G. procumbens did not show a significant effect on insulin level either in the in vivo test or the in vitro RIN-5F cell culture study. G. procumbens also showed minimal effects on β-cells of the islets of Langerhans in the pancreas. However, G. procumbens only significantly increased glucose uptake by muscle tissues. From the findings we can conclude that G. procumbens water extract exerted its hypoglycemic effect by promoting glucose uptake by muscles.
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