ReviewCurrent opinion in organ transplantation2011
Leukocyte transmigration across endothelial and extracellular matrix protein barriers in liver ischemia/reperfusion injury.
Review in Current opinion in organ transplantation, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 34 citations in OpenAlex.
- Machine Learning, scRNA-Seq and Biological Experiments Identify Hub Genes Responsible for Ischemia-Reperfusion Injury in Steatotic Liver Allografts.Journal of inflammation research · 2026Article
- Hypothermic treatment reduces matrix metalloproteinase-9 expression and damage in the liver following asphyxial cardiac arrest in rats.Laboratory animal research · 2021Article
- Sinusoidal endotheliopathy in nonalcoholic steatohepatitis: therapeutic implications.American journal of physiology. Gastrointestinal and liver physiology · 2021Review
- Elevated postischemic tissue injury and leukocyte-endothelial adhesive interactions in mice with global deficiency in caveolin-2: role of PAI-1.American journal of physiology. Heart and circulatory physiology · 2021Article
- Transient Expression of Reck Under Hepatic Ischemia/Reperfusion Conditions Is Associated with Mapk Signaling Pathways.Biomolecules · 2020Article
- Expression of Matrix Metalloproteinases and Their Tissue Inhibitors in Peripheral Blood Leukocytes and Plasma of Children with Nonalcoholic Fatty Liver Disease.Mediators of inflammation · 2020Article
- Overproduction of Tenascin-C Driven by Lipid Accumulation in the Liver Aggravates Hepatic Ischemia/Reperfusion Injury in Steatotic Mice.Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · 2019Article
- Ischemia-reperfusion injury in stroke: impact of the brain barriers and brain immune privilege on neutrophil function.Therapeutic advances in neurological disorders · 2018Review
- Protective Effects of Tormentic Acid, a Major Component of Suspension Cultures of Eriobotrya japonica Cells, on Acetaminophen-Induced Hepatotoxicity in Mice.Molecules (Basel, Switzerland) · 2017Article
- Protein kinase C-β inhibitor treatment attenuates hepatic ischemia and reperfusion injury in diabetic rats.Experimental and therapeutic medicine · 2016Article
- Tumor Necrosis Factor-Like Weak Inducer of Apoptosis Promotes Hepatic Stellate Cells Migration via Canonical NF-κB/MMP9 Pathway.PloS one · 2016Article
- Role of matrix metalloproteinases in cholestasis and hepatic ischemia/reperfusion injury: A review.World journal of gastroenterology · 2015Review
- Article
- MMP-9 deficiency shelters endothelial PECAM-1 expression and enhances regeneration of steatotic livers after ischemia and reperfusion injury.Journal of hepatology · 2014Article
- Hepatic ischemia and reperfusion injury in the absence of myeloid cell-derived COX-2 in mice.PloS one · 2014Article
- Matrix metalloproteinase-9: a deleterious link between hepatic ischemia-reperfusion and colorectal cancer.World journal of gastroenterology · 2012Article
- Fibronectin-α4β1 interactions in hepatic cold ischemia and reperfusion injury: regulation of MMP-9 and MT1-MMP via the p38 MAPK pathway.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2012Article
- TIMP-1 deficiency leads to lethal partial hepatic ischemia and reperfusion injury.Hepatology (Baltimore, Md.) · 2012Article
- Matrix metalloproteinase-9 contributes to parenchymal hemorrhage and necrosis in the remnant liver after extended hepatectomy in mice.World journal of gastroenterology · 2012Article
- Tenascin-C: a novel mediator of hepatic ischemia and reperfusion injury.Hepatology (Baltimore, Md.) · 2011Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
purpose of reviewHepatic ischemia reperfusion injury (IRI) linked to leukocyte recruitment and subsequent release of cytokines and free radicals remains a significant complication in organ transplantation. The aim of this review is to bring attention to advances made in our understanding of the mechanisms of leukocyte recruitment to sites of inflammatory stimulation in liver IRI. RECENT
findingsLeukocyte transmigration across endothelial and extracellular matrix barriers is dependent on adhesive events, as well as on focal matrix degradation mechanisms. Whereas adhesion molecules are critical for the successful promotion of leukocyte transmigration by providing leukocyte attachment to the vascular endothelium, matrix metalloproteinases (MMPs) are important for facilitating leukocyte movement across vascular barriers. Among different MMPs, MMP-9, an inducible gelatinase expressed by leukocytes during hepatic IRI, is emerging as an important mediator of leukocyte traffic to inflamed liver. SUMMARY: It is generally accepted that the understanding of the molecular mechanisms involved in leukocyte recruitment will lead to the development of novel targeted therapeutic approaches for hepatic IRI and liver transplantation. Here, we review mechanisms of leukocyte traffic in liver IRI and the role of some of the proteins that are thought to be important for this process.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.