Evidence map›Paper›PMID 21150607›Full record

ReviewCurrent opinion in organ transplantation2011

Novel functions of B cells in transplantation.

Jeffrey L Platt, Shoichiro Tsuji, Marilia Cascalho

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current opinion in organ transplantation, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Jeffrey L PlattDepartment of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA.
Shoichiro Tsuji
Marilia Cascalho
University of Michigan–Ann Arbor · US

Funding

T cell responses and cardiac transplantation in infancyP01HL079067 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PLATT, JEFFREY L · 2005 to 2009
$6.3M
Xenogeneic Natural Antibody Targets-Structure/FunctionR37HL052297 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PLATT, JEFFREY L · 2001 to 2010
$3.9M
Elements of B Cell MemoryR01AI048602 · NIAID · MAYO CLINIC COLL OF MEDICINE, ROCHESTER · PI CASCALHO, MARILIA ISABEL · 2001 to 2005
$1.5M
XENOGENEIC NATURAL ANTIBODY TARGETS--STRUCTURE/FUNCTIONR01HL052297 · NHLBI · MAYO CLINIC COLL OF MEDICINE, ROCHESTER · PI PLATT, JEFFREY L · 1993 to 2000
$319k
NHLBI NIH HHS HL52297NHLBI NIH HHS HL79067NHLBI NIH HHS P01 HL079067NHLBI NIH HHS R01 HL052297NHLBI NIH HHS R37 HL052297NIAID NIH HHS R01 AI048602
6 · The paper itself

Abstract

purpose of reviewThis manuscript reviews current knowledge and recent findings regarding antibody-independent functions of B cells in transplantation. RECENT

findingsUntil recently the functions of B cells in transplantation have been attributed almost entirely to the antibodies they produce. However, the results of recent trials of B-cell-depleting agents for treatment of antibody-mediated rejection as well as auto-immune disease raised awareness that B cells mediate functions independent of antibody synthesis. SUMMARY: These 'nonclassical' functions place B cells at the center of immune regulation with the power to enhance or inhibit immunity.

Indexed as

Transplantation ImmunologyAnimalsAntibodiesAntibody FormationB-LymphocytesGraft SurvivalHumansImmunityAntibodies

Identifiers

PMID21150607
PMCPMC4855507
OpenAlexW2326892618

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.