ReviewFly
Behavioral responses to hypoxia and hyperoxia in Drosophila larvae: molecular and neuronal sensors.
Review in Fly. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Naked mole-rats employ a normoxic escape behaviour that is altered by social interaction.Biology letters · 2025Article
- ScGOclust: leveraging gene ontology to find functionally analogous cell types between distant species.Bioinformatics (Oxford, England) · 2025Article
- The atypical soluble guanylyl cyclase subunit Gyc89Db does not control neuroepithelial proliferation inmicroPublication biology · 2024Article
- Atypical soluble guanylyl cyclases control brain size inmicroPublication biology · 2024Article
- Transcriptome analysis of FOXO-dependent hypoxia gene expression identifies Hipk as a regulator of low oxygen tolerance in Drosophila.G3 (Bethesda, Md.) · 2022Article
- Knockdown of a Cyclic Nucleotide-Gated Ion Channel Impairs Locomotor Activity and Recovery From Hypoxia in AdultFrontiers in physiology · 2022Article
- Article
- Oxygen sensing in crustaceans: functions and mechanisms.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2021Review
- Modified Atmosphere Does Not Reduce the Efficacy of Phytosanitary Irradiation Doses Recommended for Tephritid Fruit Flies.Insects · 2020Article
- A Burrowing/Tunneling Assay for Detection of Hypoxia in Drosophila melanogaster Larvae.Journal of visualized experiments : JoVE · 2018Article
- Species-specific modulation of food-search behavior by respiration and chemosensation in Drosophila larvae.eLife · 2017Article
- Failure to Burrow and Tunnel Reveals Roles for jim lovell in the Growth and Endoreplication of the Drosophila Larval Tracheae.PloS one · 2016Article
- O2-sensing neurons control CO2 response in C. elegans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Iron absorption in Drosophila melanogaster.Nutrients · 2013Review
- The neurobiology of sensing respiratory gases for the control of animal behavior.Frontiers in biology · 2012Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The ability to detect changes in oxygen concentration in the environment is critical to the survival of all animals. This requires cells to express a molecular oxygen sensor that can detect shifts in oxygen levels and transmit a signal that leads to the appropriate cellular response. Recent biochemical, genetic and behavioral studies have shown that the atypical soluble guanylyl cyclases function as oxygen detectors in Drosophila larvae triggering a behavioral escape response when exposed to hypoxia. These studies also identified the sensory neurons that innervate the terminal sensory cones as likely chemosensors that mediate this response. Here I summarize the data that led to these conclusions and also highlight evidence that suggests additional, as yet unidentified, proteins are also required for detecting increases and decreases in oxygen concentrations.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.