ArticleHuman heredity2010
The meaning of interaction.
Article in Human heredity, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
76 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Detecting fitness epistasis in recently admixed populations with genome-wide data.BMC genomics · 2020Pooled it
- Ultrafast genome-wide scan for SNP-SNP interactions in common complex disease.Genome research · 2012Pooled it
- The geometry of G × E: How scaling and endogenous treatment effects shape interaction direction.PLoS genetics · 2026Article
- CGPA: A Multicontext Cancer Gene Prognosis Atlas.Molecular cancer research : MCR · 2026Article
- Delineating markers of disease-disease interaction: a systematic methodology and its application to multiple diabetes-helminth cohorts.BMC bioinformatics · 2025Article
- The Garden of Forking Paths: Reinterpreting Haseman-Elston Regression for a Genotype-by-Environment Model.Behavior genetics · 2024Article
- An approach to identify gene-environment interactions and reveal new biological insight in complex traits.Nature communications · 2024Article
- Pushed Out and Drawn In: Exclusionary Discipline, Mental Health, and Protective Factors Among Youth in Public Schools.The Journal of school health · 2024Article
- A new Approach to Identify Gene-Environment Interactions and Reveal New Biological Insight in Complex traits.Research square · 2023Article
- Whole Genome Sequencing Revealed Inherited Rare Oligogenic Variants Contributing to Schizophrenia and Major Depressive Disorder in Two Families.International journal of molecular sciences · 2023Article
- Missing Causality and Heritability of Autoimmune Hepatitis.Digestive diseases and sciences · 2023Article
- Machine Learning Methods for Virus-Host Protein-Protein Interaction Prediction.Methods in molecular biology (Clifton, N.J.) · 2023Article
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- Detecting gene-gene interactions from GWAS using diffusion kernel principal components.BMC bioinformatics · 2022Article
- Interaction of culture and grief amongst women who terminated a pregnancy in adolescence: A narrative approach.Curationis · 2021Article
- An association study in the Taiwan Biobank elicits the GABAA receptor genes GABRB3, GABRA5, and GABRG3 as candidate loci for sleep duration in the Taiwanese population.BMC medical genomics · 2021Article
- Article
- Article
- Gene-Environment Interaction: A Variable Selection Perspective.Methods in molecular biology (Clifton, N.J.) · 2021Review
- A Single-Step Genome Wide Association Study on Body Size Traits Using Imputation-Based Whole-Genome Sequence Data in Yorkshire Pigs.Frontiers in genetics · 2021Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Although recent studies have attempted to dispel the confusion that exists in regard to the definition, analysis and interpretation of interaction in genetics, there still remain aspects that are poorly understood by non-statisticians. After a brief discussion of the definition of gene-gene interaction, the main part of this study addresses the fundamental meaning of statistical interaction and its relationship to measurement scale, disproportionate sample sizes in the cells of a two-way table and gametic phase disequilibrium.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.