Evidence map›Paper›PMID 21150005›Full record

ReviewThe Indian journal of medical research2010

Strategies for initial management of hypertension.

Rajeev Gupta, Soneil Guptha

Registry-linked trialOpen access · greenAbstract readReview
In one paragraph

Review in The Indian journal of medical research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04515095 (A Safety and Feasibility Study of Water-only Fasting and Refeeding for Treatment of Stage 1 and 2 Hypertensive Patients), which is not on this map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04515095 nacompletednot on this mapstarted 2020, after this paper: background citation

A Safety and Feasibility Study of Water-only Fasting and Refeeding for Treatment of Stage 1 and 2 Hypertensive Patients

TypeinterventionalSponsorTrueNorth Health FoundationRan2020 to 2022Enrolled30ConditionsHypertensionArmsWater-only Fasting
3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Multifaceted Biological Activity of Selected FlavoneInternational journal of molecular sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Rajeev GuptaDepartment of Medicine, Fortis-Escorts Hospital, Jaipur, India. rajeevg@satyam.net.in
Soneil Guptha
Fortis Escorts Hospital · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

High blood pressure (BP) is a major public health problem in India and its prevalence is rapidly increasing among urban and rural populations. Reducing systolic and diastolic BP can decrease cardiovascular risk and this can be achieved by non-pharmacological (lifestyle measures) as well as pharmacological means. Lifestyle changes should be the initial approach to hypertension management and include dietary interventions (reducing salt, increasing potassium, alcohol avoidance, and multifactorial diet control), weight reduction, tobacco cessation, physical exercise, and stress management. A number of pharmaceutical agents, well evidenced by large randomized clinical trials, are available for initial treatment of high BP. These include older molecules such as thiazide diuretics and beta-blocking agents and newer molecules, dihydropyridine calcium channel blockers (CCB), angiotensin converting enzyme (ACE) inhibitors, and angiotensin receptor blockers (ARB). In view of the recent clinical trials data, some international guidelines suggest that CCB, ACE inhibitors or ARB and not beta-blockers or diuretics should be the initial therapy in hypertension management. Comprehensive hypertension management focuses on reducing overall cardiovascular risk by lifestyle measures, BP lowering and lipid management and should be the preferred initial treatment approach.

Indexed as

Disease ManagementRisk Reduction BehaviorAlcoholic BeveragesAntihypertensive AgentsDietary FiberDiet, VegetarianHumansHypertensionIndiaPotassium, DietarySmokingSodium Chloride, DietaryAntihypertensive AgentsDietary FiberPotassium, DietarySodium Chloride, Dietary

Identifiers

PMID21150005
PMCPMC3028941
OpenAlexW2140850165

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.