ReviewArchives of neurology2010
The emerging role of epigenetics in stroke: II. RNA regulatory circuitry.
Review in Archives of neurology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 43 citations in OpenAlex.
- A Developmental Neuroimmune Cascade Model of Autism Spectrum Disorder.International journal of molecular sciences · 2026Review
- The Role of Antioxidants in the Connection Between Microbiota, Neuroinflammation and Epilepsy.Biomedicines · 2026Review
- Hematoma-driven immuno-epigenetic remodeling after intracerebral hemorrhage: cell-type-specific mechanisms and therapeutic opportunities.Frontiers in immunology · 2026Review
- Genetics and Epigenetics of Spontaneous Intracerebral Hemorrhage.International journal of molecular sciences · 2022Review
- The Challenge of microRNA as a Biomarker of Epilepsy.Current neuropharmacology · 2018Review
- Epigenetic interventions for epileptogenesis: A new frontier for curing epilepsy.Pharmacology & therapeutics · 2017Review
- Epigenetic Regulation of Oxidative Stress in Ischemic Stroke.Aging and disease · 2016Review
- Effects of intracerebral hemorrhage on 5-hydroxymethylcytosine modification in mouse brains.Neuropsychiatric disease and treatment · 2016Article
- Promoting brain remodeling to aid in stroke recovery.Trends in molecular medicine · 2015Review
- Moyamoya Biomarkers.Journal of Korean Neurosurgical Society · 2015Review
- Epigenetic mechanisms of neuroplasticity and the implications for stroke recovery.Experimental neurology · 2015Review
- Epigenetic impact of curcumin on stroke prevention.Metabolic brain disease · 2015Review
- Comprehensive analysis of neonatal versus adult unilateral decortication in a mouse model using behavioral, neuroanatomical, and DNA microarray approaches.International journal of molecular sciences · 2014Article
- Stroke genetics: a review and update.Journal of stroke · 2014Review
- Circulating microRNAs as potential non-invasive biomarkers for the early detection of hypertension-related stroke.Journal of human hypertension · 2014Review
- Convergent and divergent pathways decoding hierarchical additive mechanisms in treating cerebral ischemia-reperfusion injury.CNS neuroscience & therapeutics · 2014Article
- Xuezhikang therapy increases miR-33 expression in patients with low HDL-C levels.Disease markers · 2014Article
- The functional role of long non-coding RNAs and epigenetics.Biological procedures online · 2014Review
- Psychological stress as a modulator of functional recovery following spinal cord injury.Frontiers in neurology · 2014Review
- Novel protective effects of histone deacetylase inhibition on stroke and white matter ischemic injury.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Recent scientific advances have demonstrated the existence of extensive RNA-based regulatory networks involved in orchestrating nearly every cellular process in health and various disease states. This previously hidden layer of functional RNAs is derived largely from non-protein-coding DNA sequences that constitute more than 98% of the genome in humans. These non-protein-coding RNAs (ncRNAs) include subclasses that are well known, such as transfer RNAs and ribosomal RNAs, as well as those that have more recently been characterized, such as microRNAs, small nucleolar RNAs, and long ncRNAs. In this review, we examine the role of these novel ncRNAs in the nervous system and highlight emerging evidence that implicates RNA-based networks in the molecular pathogenesis of stroke. We also describe RNA editing, a related epigenetic mechanism that is partly responsible for generating the exquisite degrees of environmental responsiveness and molecular diversity that characterize ncRNAs. In addition, we discuss the development of future therapeutic strategies for locus-specific and genome-wide regulation of genes and functional gene networks through the modulation of RNA transcription, posttranscriptional RNA processing (eg, RNA modifications, quality control, intracellular trafficking, and local and long-distance intercellular transport), and RNA translation. These novel approaches for neural cell- and tissue-selective reprogramming of epigenetic regulatory mechanisms are likely to promote more effective neuroprotective and neural regenerative responses for safeguarding and even restoring central nervous system function.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.