Evidence map›Paper›PMID 21149743›Full record

Trial reportArchives of internal medicine2011

Electronic patient messages to promote colorectal cancer screening: a randomized controlled trial.

Thomas D Sequist, Alan M Zaslavsky, Graham A Colditz, John Z Ayanian

Registry-linked trialOpen access · greenAbstract readMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Archives of internal medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01032746 (Use of a Personal Health Record to Improve Colorectal Cancer Screening), which is not on this map. Cited by 55 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 9 pooled it
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01032746 naunknown statusnot on this map

Use of a Personal Health Record to Improve Colorectal Cancer Screening

TypeinterventionalSponsorHarvard UniversityRan2005Enrolled1,000ConditionsColorectal CancerArmseducational intervention, internet-based intervention, evaluation of cancer risk factors, fecal occult blood test, screening colonoscopy
3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 9 syntheses or guidelines pooled it, 89 citations in OpenAlex.

  1. Personalizing cancer risk: a systematic review of risk communication strategies.Journal of cancer research and clinical oncology · 2026
    Pooled it
  2. Decision aids for people facing health treatment or screening decisions.The Cochrane database of systematic reviews · 2024
    Pooled it
  3. Adult patient access to electronic health records.The Cochrane database of systematic reviews · 2021
    Pooled it
  4. Pooled it
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  6. Decision aids for people facing health treatment or screening decisions.The Cochrane database of systematic reviews · 2017
    Pooled it
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  18. Patient activation increases colorectal cancer screening rates: a randomized trial among low-income minority patients.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2012
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Thomas D SequistDivision of General Medicine and Primary Care, Brigham and Women's Hospital, 1620 Tremont St, Boston, MA 02120, USA. tsequist@partners.org
Alan M Zaslavsky
Graham A Colditz
John Z Ayanian
Brigham and Women's Hospital · US

Funding

Improving Systems for Colorectal Cancer ScreeningR01CA112367 · NCI · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI AYANIAN, JOHN Z. · 2005 to 2008
$1.9M
NCI NIH HHS R01 CA112367
6 · The paper itself

Abstract

backgroundColorectal cancer is a leading cause of cancer mortality, yet effective screening tests are often underused. Electronic patient messages and personalized risk assessments delivered via an electronic personal health record could increase screening rates.

methodsWe conducted a randomized controlled trial in 14 ambulatory health centers involving 1103 patients ranging in age from 50 to 75 years with an active electronic personal health record who were overdue for colorectal cancer screening. Patients were randomly assigned to receive a single electronic message highlighting overdue screening status with a link to a Web-based tool to assess their personal risk of colorectal cancer. The outcomes included colorectal cancer screening rates at 1 and 4 months.

resultsScreening rates were higher at 1 month for patients who received electronic messages than for those who did not (8.3% vs 0.2%, P < .001), but this difference was no longer significant at 4 months (15.8% vs 13.1%, P = .18). Of 552 patients randomized to receive the intervention, 296 (54%) viewed the message, and 47 (9%) used the Web-based risk assessment tool. Among 296 intervention patients who viewed the electronic message, risk tool users were more likely than nonusers to request screening examinations (17% vs 4%, P = .04) and to be screened (30% vs 15%, P = .06). One-fifth of patients (19%) using the risk assessment tool were estimated to have an above-average risk for colorectal cancer.

conclusionElectronic messages to patients produce an initial increase in colorectal cancer screening rates, but this effect is not sustained over time.

trial registrationclinicaltrials.gov Identifier: NCT01032746.

Indexed as

ColonoscopyReminder SystemsAgedColorectal NeoplasmsFemaleHealth Records, PersonalHumansInternetMaleMass ScreeningMiddle AgedRisk Assessment

Identifiers

PMID21149743
PMCPMC3169179
OpenAlexW2075497490

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.