ArticleProceedings of the National Academy of Sciences of the United States of America2011
Model of pediatric pituitary hormone deficiency separates the endocrine and neural functions of the LHX3 transcription factor in vivo.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Genomic analyses identify agents regulating somatotroph and lactotroph functions.Functional & integrative genomics · 2016Pooled it
- A Novel LHX3 Variant Associated With Combined Pituitary Hormone Deficiency in an Indian Kindred.Cureus · 2026Article
- A Nonsynonymous Substitution ofGenes · 2024Article
- Dwarfism in Tibetan Terrier dogs with anJournal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2021Article
- Heterozygous LHX3 mutations may lead to a mild phenotype of combined pituitary hormone deficiency.European journal of human genetics : EJHG · 2019Article
- Article
- Developmental analysis and influence of genetic background on the Lhx3 W227ter mouse model of combined pituitary hormone deficiency disease.Endocrinology · 2013Article
- LHX3 interacts with inhibitor of histone acetyltransferase complex subunits LANP and TAF-1β to modulate pituitary gene regulation.PloS one · 2013Article
- A distal modular enhancer complex acts to control pituitary- and nervous system-specific expression of the LHX3 regulatory gene.Molecular endocrinology (Baltimore, Md.) · 2012Article
- Genome-wide association studies for multiple diseases of the German Shepherd Dog.Mammalian genome : official journal of the International Mammalian Genome Society · 2012Article
- A recessive mutation resulting in a disabling amino acid substitution (T194R) in the LHX3 homeodomain causes combined pituitary hormone deficiency.Hormone research in paediatrics · 2012Article
- A novel alignment method and multiple filters for exclusion of unqualified peptides to enhance label-free quantification using peptide intensity in LC-MS/MS.Journal of proteome research · 2011Article
- The role of homeodomain transcription factors in heritable pituitary disease.Nature reviews. Endocrinology · 2011Review
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The etiology of most pediatric hormone deficiency diseases is poorly understood. Children with combined pituitary hormone deficiency (CPHD) have insufficient levels of multiple anterior pituitary hormones causing short stature, metabolic disease, pubertal failure, and often have associated nervous system symptoms. Mutations in developmental regulatory genes required for the specification of the hormone-secreting cell types of the pituitary gland underlie severe forms of CPHD. To better understand these diseases, we have created a unique mouse model of CPHD with a targeted knockin mutation (Lhx3 W227ter), which is a model for the human LHX3 W224ter disease. The LHX3 gene encodes a LIM-homeodomain transcription factor, which has essential roles in pituitary and nervous system development in mammals. The introduced premature termination codon results in deletion of the carboxyl terminal region of the LHX3 protein, which is critical for pituitary gene activation. Mice that lack all LHX3 function do not survive beyond birth. By contrast, the homozygous Lhx3 W227ter mice survive, but display marked dwarfism, thyroid disease, and female infertility. Importantly, the Lhx3 W227ter mice have no apparent nervous system deficits. The Lhx3 W227ter mouse model provides a unique array of hormone deficits and facilitates experimental approaches that are not feasible with human patients. These experiments demonstrate that the carboxyl terminus of the LHX3 transcription factor is not required for viability. More broadly, this study reveals that the in vivo actions of a transcription factor in different tissues are molecularly separable.
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