ArticleProceedings of the National Academy of Sciences of the United States of America2011
Lateral acquisition of genes is affected by the friendliness of their products.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed.
- Evolution of the connectivity and indispensability of a transferable gene: the simplicity hypothesis.BMC ecology and evolution · 2022Article
- Evolutionary assembly patterns of prokaryotic genomes.Genome research · 2016Article
- Pangenome evidence for extensive interdomain horizontal transfer affecting lineage core and shell genes in uncultured planktonic thaumarchaeota and euryarchaeota.Genome biology and evolution · 2014Article
- Recurrent horizontal transfer of bacterial toxin genes to eukaryotes.Molecular biology and evolution · 2012Article
- High expression hampers horizontal gene transfer.Genome biology and evolution · 2012Article
- Alternative protein-protein interfaces are frequent exceptions.PLoS computational biology · 2012Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A major factor in the evolution of microbial genomes is the lateral acquisition of genes that evolved under the functional constraints of other species. Integration of foreign genes into a genome that has different components and circuits poses an evolutionary challenge. Moreover, genes belonging to complex modules in the pretransfer species are unlikely to maintain their functionality when transferred alone to new species. Thus, it is widely accepted that lateral gene transfer favors proteins with only a few protein-protein interactions. The propensity of proteins to participate in protein-protein interactions can be assessed using computational methods that identify putative interaction sites on the protein. Here we report that laterally acquired proteins contain significantly more putative interaction sites than native proteins. Thus, genes encoding proteins with multiple protein-protein interactions may in fact be more prone to transfer than genes with fewer interactions. We suggest that these proteins have a greater chance of forming new interactions in new species, thus integrating into existing modules. These results reveal basic principles for the incorporation of novel genes into existing systems.
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