ArticleProceedings of the National Academy of Sciences of the United States of America2010
Spatio-temporal sequence of cross-regulatory events in root meristem growth.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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Who cites it
60 citing papers in PubMed.
- Grafting reveals organ-autonomous and feedback roles of root phloem development in source-sink dynamics.Journal of experimental botany · 2026Article
- Regulatory Mechanisms Underlying Stem Strength and Toughness in Dicotyledonous Plants: Implications for Soybean Breeding.Current issues in molecular biology · 2026Review
- Fine mapping and candidate gene mining of major QTLFrontiers in plant science · 2025Article
- Crosstalk among plant hormone regulates the root development.Plant signaling & behavior · 2024Review
- Metabolomics and transcriptomics combined with physiology reveal key metabolic pathway responses in tobacco roots exposed to NaHS.BMC plant biology · 2024Article
- Comprehensive identification and systematical characterization of BRX gene family and the functional of GhBRXL5A in response to salt stress.BMC plant biology · 2024Article
- Enigmatic role of auxin response factors in plant growth and stress tolerance.Frontiers in plant science · 2024Review
- Hormonal control of the molecular networks guiding vascular tissue development in the primary root meristem of Arabidopsis.Journal of experimental botany · 2023Review
- How to explore what is hidden? A review of techniques for vascular tissue expression profile analysis.Plant methods · 2023Review
- Maintenance of stem cell activity in plant development and stress responses.Frontiers in plant science · 2023Review
- A root phloem pole cell atlas reveals common transcriptional states in protophloem-adjacent cells.Nature plants · 2022Article
- A Dof-CLE circuit controls phloem organization.Nature plants · 2022Article
- Receptor-like cytoplasmic kinases PBL34/35/36 are required for CLE peptide-mediated signaling to maintain shoot apical meristem and root apical meristem homeostasis in Arabidopsis.The Plant cell · 2022Article
- Auxin Interactions with Other Hormones in Plant Development.Cold Spring Harbor perspectives in biology · 2021Review
- Mapping and engineering of auxin-induced plasma membrane dissociation in BRX family proteins.The Plant cell · 2021Article
- Of Cells, Strands, and Networks: Auxin and the Patterned Formation of the Vascular System.Cold Spring Harbor perspectives in biology · 2021Review
- Divergence of three BRX homoeologs in Brassica rapa and its effect on leaf morphology.Horticulture research · 2021Article
- Genome-Wide Association Study of Natural Variation inPlants (Basel, Switzerland) · 2021Article
- The value of asymmetry: how polarity proteins determine plant growth and morphology.Journal of experimental botany · 2020Article
- Regulation of auxin transcriptional responses.Developmental dynamics : an official publication of the American Association of Anatomists · 2020Review
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8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
A central question in developmental biology is how multicellular organisms coordinate cell division and differentiation to determine organ size. In Arabidopsis roots, this balance is controlled by cytokinin-induced expression of SHORT HYPOCOTYL 2 (SHY2) in the so-called transition zone of the meristem, where SHY2 negatively regulates auxin response factors (ARFs) by protein-protein interaction. The resulting down-regulation of PIN-FORMED (PIN) auxin efflux carriers is considered the key event in promoting differentiation of meristematic cells. Here we show that this regulation involves additional, intermediary factors and is spatio-temporally constrained. We found that the described cytokinin-auxin crosstalk antagonizes BREVIS RADIX (BRX) activity in the developing protophloem. BRX is an auxin-responsive target of the prototypical ARF MONOPTEROS (MP), a key promoter of vascular development, and transiently enhances PIN3 expression to promote meristem growth in young roots. At later stages, cytokinin induction of SHY2 in the vascular transition zone restricts BRX expression to down-regulate PIN3 and thus limit meristem growth. Interestingly, proper SHY2 expression requires BRX, which could reflect feedback on the auxin responsiveness of SHY2 because BRX protein can directly interact with MP, likely acting as a cofactor. Thus, cross-regulatory antagonism between BRX and SHY2 could determine ARF activity in the protophloem. Our data suggest a model in which the regulatory interactions favor BRX expression in the early proximal meristem and SHY2 prevails because of supplementary cytokinin induction in the later distal meristem. The complex equilibrium of this regulatory module might represent a universal switch in the transition toward differentiation in various developmental contexts.
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