ArticleProceedings of the National Academy of Sciences of the United States of America2011
Active scaffolds for on-demand drug and cell delivery.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 152 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
152 citing papers in PubMed.
- 3D Printing of Magnetic Soft Materials for Functional Structures and Devices.Advanced materials (Deerfield Beach, Fla.) · 2026Review
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- Soft 3D electromagnetic structures with rapid, complex shape morphing.Science advances · 2025Article
- Vat Photopolymerization of Smart Polymers for Biomedical Applications.ACS applied polymer materials · 2025Review
- Magnetic-Driven Viscous Mechanisms in Ultra-Soft Magnetorheological Elastomers Offer History-Dependent Actuation with Reprogrammability Options.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Mechanical and Light Activation of Materials for Chemical Production.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- A Simple Method to Determine Diffusion Coefficients in Soft Hydrogels for Drug Delivery and Biomedical Applications.ACS omega · 2025Article
- Magnetomechanical Behaviors of Hard-Magnetic Elastomer Membranes Placed in Uniform Magnetic Field.Materials (Basel, Switzerland) · 2024Article
- Biomaterials functionalized with magnetic nanoparticles for tissue engineering: Between advantages and challenges.Biomaterials and biosystems · 2024Article
- Smart Multi-Responsive Biomaterials and Their Applications for 4D Bioprinting.Biomimetics (Basel, Switzerland) · 2024Review
- Modeling of Magnetic Scaffolds as Drug Delivery Platforms for Tissue Engineering and Cancer Therapy.Bioengineering (Basel, Switzerland) · 2024Article
- Advances in Hydrogel-Based Drug Delivery Systems.Gels (Basel, Switzerland) · 2024Review
- Bio-Hybrid Magnetic Robots: From Bioengineering to Targeted Therapy.Bioengineering (Basel, Switzerland) · 2024Review
- Elastocapillary rolling transfer weaves soft materials to spatial structures.Science advances · 2023Article
- Diffusion-Limited Processes in Hydrogels with Chosen Applications from Drug Delivery to Electronic Components.Molecules (Basel, Switzerland) · 2023Review
- A review on the effect of nanocomposite scaffolds reinforced with magnetic nanoparticles in osteogenesis and healing of bone injuries.Stem cell research & therapy · 2023Review
- Lifelike Transformative Materials for Biohybrid Implants: Inspired by Nature, Driven by Technology.Advanced healthcare materials · 2023Article
- Curing spurious magneto-mechanical coupling in soft non-magnetic materials.International journal for numerical methods in engineering · 2023Article
- Article
92 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Porous biomaterials have been widely used as scaffolds in tissue engineering and cell-based therapies. The release of biological agents from conventional porous scaffolds is typically governed by molecular diffusion, material degradation, and cell migration, which do not allow for dynamic external regulation. We present a new active porous scaffold that can be remotely controlled by a magnetic field to deliver various biological agents on demand. The active porous scaffold, in the form of a macroporous ferrogel, gives a large deformation and volume change of over 70% under a moderate magnetic field. The deformation and volume variation allows a new mechanism to trigger and enhance the release of various drugs including mitoxantrone, plasmid DNA, and a chemokine from the scaffold. The porous scaffold can also act as a depot of various cells, whose release can be controlled by external magnetic fields.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.