ArticleProceedings of the National Academy of Sciences of the United States of America2011
Visualizing key hinges and a potential major source of compliance in the lever arm of myosin.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 30 citations in OpenAlex.
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- Interacting myosin head dynamics and their modification by 2'-deoxy-ADP.Biophysical journal · 2024Article
- Double-headed binding of myosin II to F-actin shows the effect of strain on head structure.Journal of structural biology · 2023Article
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- Novel blood coagulation molecules: Skeletal muscle myosin and cardiac myosin.Journal of thrombosis and haemostasis : JTH · 2021Review
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- Myosin lever arm orientation in muscle determined with high angular resolution using bifunctional spin labels.The Journal of general physiology · 2019Article
- Chemical Crosslinking Mass Spectrometry Analysis of Protein Conformations and Supercomplexes in Heart Tissue.Cell systems · 2018Article
- Structure of myosin filaments from relaxedScience advances · 2016Article
- Made to measure - keeping Rho kinase at a distance.Small GTPases · 2016Review
- Orientation of the N- and C-terminal lobes of the myosin regulatory light chain in cardiac muscle.Biophysical journal · 2015Article
- Getting the skinny on thick filament regulation in cardiac muscle biology and disease.Trends in cardiovascular medicine · 2014Review
- Role of the essential light chain in the activation of smooth muscle myosin by regulatory light chain phosphorylation.Journal of structural biology · 2014Article
- Flexibility within the heads of muscle myosin-2 molecules.Journal of molecular biology · 2014Article
- Myosin light chains: Teaching old dogs new tricks.Bioarchitecture · 2014Review
- Mammalian myosin-18A, a highly divergent myosin.The Journal of biological chemistry · 2013Article
- Isoform level expression profiles provide better cancer signatures than gene level expression profiles.Genome medicine · 2013Article
- Mesoscopic analysis of motion and conformation of cross-bridges.Biophysical reviews · 2012Review
- The effect of myosin RLC phosphorylation in normal and cardiomyopathic mouse hearts.Journal of cellular and molecular medicine · 2012Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
We have determined the 2.3-Å-resolution crystal structure of a myosin light chain domain, corresponding to one type found in sea scallop catch ("smooth") muscle. This structure reveals hinges that may function in the "on" and "off" states of myosin. The molecule adopts two different conformations about the heavy chain "hook" and regulatory light chain (RLC) helix D. This conformational change results in extended and compressed forms of the lever arm whose lengths differ by 10 Å. The heavy chain hook and RLC helix D hinges could thus serve as a potential major and localized source of cross-bridge compliance during the contractile cycle. In addition, in one of the molecules of the crystal, part of the RLC N-terminal extension is seen in atomic detail and forms a one-turn alpha-helix that interacts with RLC helix D. This extension, whose sequence is highly variable in different myosins, may thus modulate the flexibility of the lever arm. Moreover, the relative proximity of the phosphorylation site to the helix D hinge suggests a potential role for conformational changes about this hinge in the transition between the on and off states of regulated myosins.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.