ArticleInfection and immunity2011
Differential effects of three canonical Toxoplasma strains on gene expression in human neuroepithelial cells.
Article in Infection and immunity, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Article
- Blockade of Tim-3 pathway in a mouse model of Toxoplasmosis: impact on brain leukocyte infiltration, parasite burden, and neuroinflammation.Scientific reports · 2026Article
- Article
- Toxoplasma gondii seropositivity in patients with depressive and anxiety disorders.Brain, behavior, & immunity - health · 2021Article
- Mucosal Administration of Recombinant Baculovirus DisplayingFrontiers in cellular and infection microbiology · 2021Article
- PersistentInfection and immunity · 2019Article
- Brazilian strains of Toxoplasma gondii are controlled by azithromycin and modulate cytokine production in human placental explants.Journal of biomedical science · 2019Article
- Mechanisms of Human Innate Immune Evasion byFrontiers in cellular and infection microbiology · 2019Review
- Toxoplasma gondii: Biological Parameters of the Connection to Schizophrenia.Schizophrenia bulletin · 2018Review
- A NewScientifica · 2018Article
- Toxoplasma genotyping in congenital toxoplasmosis in Upper Egypt: evidence of type I strain.Parasitology research · 2017Article
- Cerebral complement C1q activation in chronic Toxoplasma infection.Brain, behavior, and immunity · 2016Article
- Autoimmune diseases, gastrointestinal disorders and the microbiome in schizophrenia: more than a gut feeling.Schizophrenia research · 2016Review
- Patterns of Hydrocephalus Caused by Congenital Toxoplasma gondii Infection Associate With Parasite Genetics.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2015Article
- Genome-wide expression analysis comparing hypertrophic changes in normal and dysferlinopathy mice.Genomics data · 2015Article
- Muscle hypertrophy induced by myostatin inhibition accelerates degeneration in dysferlinopathy.Human molecular genetics · 2015Article
- Chronic infection of Toxoplasma gondii downregulates miR-132 expression in multiple brain regions in a sex-dependent manner.Parasitology · 2015Article
- Strain hypothesis of Toxoplasma gondii infection on the outcome of human diseases.Acta physiologica (Oxford, England) · 2015Review
- Toxoplasma gondii prevalent in China induce weaker apoptosis of neural stem cells C17.2 via endoplasmic reticulum stress (ERS) signaling pathways.Parasites & vectors · 2015Article
- MicroRNA-132 dysregulation in Toxoplasma gondii infection has implications for dopamine signaling pathway.Neuroscience · 2014Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Strain type is one of the key factors suspected to play a role in determining the outcome of Toxoplasma infection. In this study, we examined the transcriptional profile of human neuroepithelioma cells in response to representative strains of Toxoplasma by using microarray analysis to characterize the strain-specific host cell response. The study of neural cells is of interest in light of the ability of Toxoplasma to infect the brain and to establish persistent infection within the central nervous system. We found that the extents of the expression changes varied considerably among the three strains. Neuroepithelial cells infected with Toxoplasma type I exhibited the highest level of differential gene expression, whereas type II-infected cells had a substantially smaller number of genes which were differentially expressed. Cells infected with type III exhibited intermediate effects on gene expression. The three strains also differed in the individual genes and gene pathways which were altered following cellular infection. For example, gene ontology (GO) analysis indicated that type I infection largely affects genes related to the central nervous system, while type III infection largely alters genes which affect nucleotide metabolism; type II infection does not alter the expression of a clearly defined set of genes. Moreover, Ingenuity Pathways Analysis (IPA) suggests that the three lineages differ in the ability to manipulate their host; e.g., they employ different strategies to avoid, deflect, or subvert host defense mechanisms. These observed differences may explain some of the variation in the neurobiological effects of different strains of Toxoplasma on infected individuals.
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