ReviewThe Journal of general physiology2011
Mining recent brain proteomic databases for ion channel phosphosite nuggets.
Review in The Journal of general physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Review
- Spectrum of KAnnals of neurology · 2019Article
- Protein phosphorylation maintains the normal function of cloned human CaThe Journal of general physiology · 2018Article
- In vitro and in vivo phosphorylation of the CaChannels (Austin, Tex.) · 2018Review
- Article
- An update on transcriptional and post-translational regulation of brain voltage-gated sodium channels.Amino acids · 2016Review
- A unique ion channel clustering domain on the axon initial segment of mammalian neurons.The Journal of comparative neurology · 2014Article
- The sodium leak channel, NALCN, in health and disease.Frontiers in cellular neuroscience · 2014Review
- Mass spectrometry-based identification of native cardiac Nav1.5 channel α subunit phosphorylation sites.Journal of proteome research · 2012Article
- Trafficking mechanisms underlying neuronal voltage-gated ion channel localization at the axon initial segment.Epilepsia · 2012Review
- Ion channels and schizophrenia: a gene set-based analytic approach to GWAS data for biological hypothesis testing.Human genetics · 2012Article
- Control of neuronal ion channel function by glycogen synthase kinase-3: new prospective for an old kinase.Frontiers in molecular neuroscience · 2012Article
- Cytoplasmic domains and voltage-dependent potassium channel gating.Frontiers in pharmacology · 2012Article
- Repolarizing cardiac potassium channels: multiple sites and mechanisms for CaMKII-mediated regulation.Heart rhythm · 2011Review
- A SUMO-Phospho tag team for wrestling with potassium channel gating.The Journal of general physiology · 2011Article
- Post-translational modification: nature's escape from genetic imprisonment and the basis for dynamic information encoding.Wiley interdisciplinary reviews. Systems biology and medicineReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Voltage-gated ion channels underlie electrical activity of neurons and are dynamically regulated by diverse cell signaling pathways that alter their phosphorylation state. Recent global mass spectrometric-based analyses of the mouse brain phosphoproteome have yielded a treasure trove of new data as to the extent and nature of phosphorylation of numerous ion channel principal or α subunits in mammalian brain. Here we compile and review data on 347 phosphorylation sites (261 unique) on 42 different voltage-gated ion channel α subunits that were identified in these recent studies. Researchers in the ion channel field can now begin to explore the role of these novel in vivo phosphorylation sites in the dynamic regulation of the localization, activity, and expression of brain ion channels through multisite phosphorylation of their principal subunits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.