ArticleThe Journal of physiology2011
Imbalanced K+ and Ca2+ subthreshold interactions contribute to increased hypothalamic presympathetic neuronal excitability in hypertensive rats.
Article in The Journal of physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Article
- Multiple time points of transcriptome analysis revealed altered genes involved in maintaining hibernation in the hypothalamus ofFrontiers in neuroscience · 2024Article
- Angiotensin II inhibits the A-type KAmerican journal of physiology. Regulatory, integrative and comparative physiology · 2022Article
- Identification of Novel Cross-Talk between the Neuroendocrine and Autonomic Stress Axes Controlling Blood Pressure.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Functional coupling between NMDA receptors and SK channels in rat hypothalamic magnocellular neurons: altered mechanisms during heart failure.The Journal of physiology · 2021Article
- Exacerbated effects of prorenin on hypothalamic magnocellular neuronal activity and vasopressin plasma levels during salt-sensitive hypertension.American journal of physiology. Heart and circulatory physiology · 2019Article
- NMDA receptors potentiate activity-dependent dendritic release of neuropeptides from hypothalamic neurons.The Journal of physiology · 2019Article
- Hypothalamic Ion Channels in Hypertension.Current hypertension reports · 2018Review
- Ion Channels in the Paraventricular Hypothalamic Nucleus (PVN); Emerging Diversity and Functional Roles.Frontiers in physiology · 2018Review
- A reduction in SK channels contributes to increased activity of hypothalamic magnocellular neurons during heart failure.The Journal of physiology · 2017Article
- A-type KAmerican journal of physiology. Heart and circulatory physiology · 2017Article
- An increased extrasynaptic NMDA tone inhibits A-type KThe Journal of physiology · 2017Article
- Mechanisms underlying prorenin actions on hypothalamic neurons implicated in cardiometabolic control.Molecular metabolism · 2016Article
- A Functional Coupling Between Carbon Monoxide and Nitric Oxide Contributes to Increased Vasopressin Neuronal Activity in Heart Failure rats.Endocrinology · 2016Article
- ATP stimulates rat hypothalamic sympathetic neurons by enhancing AMPA receptor-mediated currents.Journal of neurophysiology · 2015Article
- Toll-like receptor 4 inhibition within the paraventricular nucleus attenuates blood pressure and inflammatory response in a genetic model of hypertension.Journal of neuroinflammation · 2015Article
- A functional coupling between extrasynaptic NMDA receptors and A-type K+ channels under astrocyte control regulates hypothalamic neurosecretory neuronal activity.The Journal of physiology · 2014Article
- Estrogen replacement modulates voltage-gated potassium channels in rat presympathetic paraventricular nucleus neurons.BMC neuroscience · 2013Article
- Enhanced NMDA receptor-mediated intracellular calcium signaling in magnocellular neurosecretory neurons in heart failure rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Article
- Dendritic peptide release mediates interpopulation crosstalk between neurosecretory and preautonomic networks.Neuron · 2013Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Despite the importance of brain-mediated sympathetic activation in the morbidity and mortality of patients with high blood pressure, the precise cellular mechanisms involved remain largely unknown. We show that an imbalanced interaction between two opposing currents mediated by potassium (I(A)) and calcium (I(T)) channels occurs in sympathetic-related hypothalamic neurons in hypertensive rats. We show that this imbalance contributes to enhanced membrane excitability and firing activity in this neuronal population. Knowledge of how these opposing ion channels interact in normal and disease states increases our understanding of underlying brain mechanisms contributing to the high blood pressure condition.
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Registered trials
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