ArticleDisaster medicine and public health preparedness2010
A modified sequential organ failure assessment score for critical care triage.
Article in Disaster medicine and public health preparedness, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07068022 (Development and Validation of an Obstetric Organ Dysfunction Score to Predict Mortality in Intensive Care Unit), which is not on this map. Cited by 89 papers, 5 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Development and Validation of an Obstetric Organ Dysfunction Score to Predict Mortality in Intensive Care Unit: A Multicenter, Prospective, Cohort Study
Who cites it
89 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Efficacy and safety outcomes reported in human leptospirosis studies to inform the development of a core outcome and core outcome measurement set: A systematic review.PLoS neglected tropical diseases · 2026Pooled it
- A Review of Mortality Risk Prediction Models in Smartphone Applications.Journal of medical systems · 2021Pooled it
- Crisis Standards of Care in the USA: A Systematic Review and Implications for Equity Amidst COVID-19.Journal of racial and ethnic health disparities · 2021Pooled it
- Allocation of Scarce Resources in a Pandemic: A Systematic Review of US State Crisis Standards of Care Documents.Disaster medicine and public health preparedness · 2020Pooled it
- Performance of critical care prognostic scoring systems in low and middle-income countries: a systematic review.Critical care (London, England) · 2018Pooled it
- Facilitating Safe Discharge Through Predicting Disease Progression in Moderate Coronavirus Disease 2019 (COVID-19): A Prospective Cohort Study to Develop and Validate a Clinical Prediction Model in Resource-Limited Settings.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022Trial
- Interobserver Agreement for Classifying Infections in Emergency Department Patients Using Modified Centers for Disease Control and Prevention Criteria.Open forum infectious diseases · 2026Article
- Comparative performance of APACHE II, SOFA, and Charlson Comorbidity Index in sepsis mortality prediction.Biomolecules & biomedicine · 2026Observational
- A simplified Sequential Organ Failure Assessment score is associated with 30-day trauma mortality: A novel tool for a low-resource practice setting.The journal of trauma and acute care surgery · 2026Observational
- Real-world longitudinal validation of high-income-country-derived sepsis endotypes in sub-Saharan Africa: a nested prospective multicenter study.Critical care (London, England) · 2026Article
- Evaluation of 6-hour urine creatinine clearance as the kidney component in the SOFA score: An observational cohort study.Journal of intensive medicine · 2026Article
- Critical care in Gaza amidst military pressure: the struggle of healthcare workers in Gaza's Warzone.BMJ global health · 2025Article
- Towards novel BIOmarkers to diagnose SEPsis (BIOSEP) in the emergency room: a protocol for a multicentre, prospective cohort study.BMJ open · 2025Article
- A deep learning model for clinical outcome prediction using longitudinal inpatient electronic health records.JAMIA open · 2025Article
- Development and Validation of a Risk Score for Predicting ICU Admission in Adults with New-Onset Encephalitis.Neurocritical care · 2025Article
- Validation of the REDS score in hospitalised patients who deteriorated and were admitted to the intensive care unit-a retrospective cohort study.BMJ open quality · 2025Article
- Observational
- Decreased levels and function of dendritic cells in blood and airways predict COVID-19 severity.Clinical & translational immunology · 2025Article
- Tools for Screening, Predicting, and Evaluating Sepsis and Septic Shock: A Comprehensive Review.Cureus · 2024Review
- Article
29 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
objectiveThe Sequential Organ Failure Assessment (SOFA) score has been recommended for triage during a mass influx of critically ill patients, but it requires laboratory measurement of 4 parameters, which may be impractical with constrained resources. We hypothesized that a modified SOFA (MSOFA) score that requires only 1 laboratory measurement would predict patient outcome as effectively as the SOFA score.
methodsAfter a retrospective derivation in a prospective observational study in a 24-bed medical, surgical, and trauma intensive care unit, we determined serial SOFA and MSOFA scores on all patients admitted during the 2008 calendar year and compared the ability to predict mortality and the need for mechanical ventilation.
resultsA total of 1770 patients (56% male patients) with a 30-day mortality of 10.5% were included in the study. Day 1 SOFA and MSOFA scores performed equally well at predicting mortality with an area under the receiver operating curve (AUC) of 0.83 (95% confidence interval 0.81-.85) and 0.84 (95% confidence interval 0.82-.85), respectively (P = .33 for comparison). Day 3 SOFA and MSOFA predicted mortality for the 828 patients remaining in the intensive care unit with an AUC of 0.78 and 0.79, respectively. Day 5 scores performed less well at predicting mortality. Day 1 SOFA and MSOFA predicted the need for mechanical ventilation on day 3, with an AUC of 0.83 and 0.82, respectively. Mortality for the highest category of SOFA and MSOFA score (>11 points) was 53% and 58%, respectively.
conclusionsThe MSOFA predicts mortality as well as the SOFA and is easier to implement in resource-constrained settings, but using either score as a triage tool would exclude many patients who would otherwise survive.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.