Evidence map›Paper›PMID 21148449›Full record

ReviewCirculation research2010

Myocardial lineage development.

Sylvia M Evans, Deborah Yelon, Frank L Conlon, Margaret L Kirby

Open access · bronzeAbstract readReview
In one paragraph

Review in Circulation research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 165 papers.

0numbers the graph read from it
0cells of the map it votes in
165citing papers in PubMed
9.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

165 citing papers in PubMed, 286 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. A simple approach of nuclei isolation for single nucleus multiome sequencing.Journal of molecular and cellular cardiology · 2025
    Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Tracking Somatic Mutations for Lineage Reconstruction.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Cardiac Development and Animal Models of Congenital Heart Defects.Advances in experimental medicine and biology · 2024
    Review
  20. Macrophage lineages in heart development and regeneration.Current topics in developmental biology · 2024
    Review

105 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Sylvia M EvansSkaggs School of Pharmacy and Pharmaceutical Sciences, Department of Medicine, University of California San Diego, 9500 Gilman Dr, La Jolla CA 92093, USA. syevans@ucsd.edu
Deborah Yelon
Frank L Conlon
Margaret L Kirby
University of California, San Diego · USUniversity of Montana · US

Funding

REGULATION AND FUNCTION OF THE OUTFLOW SEPTATION COMPLEXP01HL036059 · NHLBI · MEDICAL COLLEGE OF GEORGIA (MCG) · PI KIRBY, MARGARET LOEWY · 1986 to 2004
$8.1M
Genetic Regulation of Cardiac Patterning in ZebrafishR01HL069594 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI YELON, DEBORAH · 2002 to 2015
$4.0M
Mechanisms of Islet1 Action in Heart DevelopmentR01HL074066 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI EVANS, SYLVIA M · 2003 to 2011
$3.3M
The Role of Tbox20 in Cardiac Development & Adult HeartR01HL070867 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI EVANS, SYLVIA M · 2002 to 2010
$3.1M
Approaches to Cardiac RegenerationDP1OD006428 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI EVANS, SYLVIA M · 2009 to 2011
$2.3M
Craniofacial and cardiac development in Xenopus: A genetic approachR01DE018825 · NIDCR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CONLON, FRANK LEO, KHOKHA, MUSTAFA K · 2009 to 2013
$2.3M
Neural Crest Modulates FGF Signaling in the PharynxR01HL083240 · NHLBI · DUKE UNIVERSITY · PI KIRBY, MARGARET LOEWY · 2006 to 2010
$2.1M
TBX5 and cardiac proliferationR01HL089641 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CONLON, FRANK LEO · 2008 to 2011
$1.5M
Characterization of Secondary Heart FieldR01HL070140 · NHLBI · DUKE UNIVERSITY · PI KIRBY, MARGARET LOEWY · 2003 to 2006
$1.2M
NHLBI NIH HHS HL036059NHLBI NIH HHS HL069594NHLBI NIH HHS HL070140NHLBI NIH HHS HL083240NHLBI NIH HHS HL089641NHLBI NIH HHS P01 HL036059NHLBI NIH HHS R01 HL069594NHLBI NIH HHS R01 HL070140NHLBI NIH HHS R01 HL070867NHLBI NIH HHS R01 HL074066NHLBI NIH HHS R01 HL083240NHLBI NIH HHS R01 HL089641NIDCR NIH HHS DE018825NIDCR NIH HHS R01 DE018825NIH HHS DP1 OD006428
6 · The paper itself

Abstract

The myocardium of the heart is composed of multiple highly specialized myocardial lineages, including those of the ventricular and atrial myocardium, and the specialized conduction system. Specification and maturation of each of these lineages during heart development is a highly ordered, ongoing process involving multiple signaling pathways and their intersection with transcriptional regulatory networks. Here, we attempt to summarize and compare much of what we know about specification and maturation of myocardial lineages from studies in several different vertebrate model systems. To date, most research has focused on early specification, and although there is still more to learn about early specification, less is known about factors that promote subsequent maturation of myocardial lineages required to build the functioning adult heart.

Indexed as

Cell LineageAnimalsHeartHumansMyocardiumMyocytes, Cardiac

Identifiers

PMID21148449
PMCPMC3073310
OpenAlexW2110275759

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.