ReviewStroke2011
Pumps, aqueducts, and drought management: vascular physiology in vascular cognitive impairment.
Review in Stroke, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05396287 (The Impact of Cerebral Anatomical Variations on Cerebrovascular Reactivity), which is not on this map. Cited by 38 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Impact of Cerebral Anatomical Variations on Cerebrovascular Reactivity
Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- Therapeutic Strategies and Drug Development for Vascular Cognitive Impairment.Journal of the American Heart Association · 2017Pooled it
- Long-term effects of almond consumption on cognitive performance and brain vascular function: a randomized crossover trial in overweight/obese adults with prediabetes.European journal of clinical nutrition · 2026Trial
- Long-term egg-protein hydrolysate consumption improves endothelial function: a randomized, double-blind, placebo-controlled trial in older adults with overweight or obesity.European journal of nutrition · 2024Trial
- Long-term effects of an egg-protein hydrolysate on cognitive performance and brain vascular function: a double-blind randomized controlled trial in adults with elevated subjective cognitive failures.European journal of nutrition · 2024Trial
- Determining the effects of elevated partial pressure of oxygen on hypercapnia-induced cerebrovascular reactivity.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- Associations of intracranial artery length and branch number on non-contrast enhanced MRA with cognitive impairment in individuals with carotid atherosclerosis.Scientific reports · 2022Article
- Baseline Cognitive Impairment in Patients With Asymptomatic Carotid Stenosis in the CREST-2 Trial.Stroke · 2021Article
- Correlates of deep brain stimulation consensus conference decision to treat primary dystonia.Clinical neurology and neurosurgery · 2021Article
- A Primary Care Agenda for Brain Health: A Scientific Statement From the American Heart Association.Stroke · 2021Review
- Magnetic Resonance Imaging in Childhood Primary Hypertension: Potential in the Study of Cognitive Outcomes.Hypertension (Dallas, Tex. : 1979) · 2021Review
- Long-term cognitive decline and mortality after carotid endarterectomy.Clinical neurology and neurosurgery · 2020Article
- Poststroke Montreal Cognitive Assessment and Recurrent Stroke in Patients With Symptomatic Intracranial Atherosclerosis.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2020Article
- Cognitive Impairment Correlates Linearly with Mean Flow Velocity by Transcranial Doppler below a Definable Threshold.Cerebrovascular diseases extra · 2020Article
- Cerebral Artery Hypoplasia in a Select Adult Kenyan Population.Journal of neurosciences in rural practice · 2019Article
- Is Hemispheric Hypoperfusion a Treatable Cause of Cognitive Impairment?Current cardiology reports · 2019Review
- Cerebral Hemodynamics in Sleep Apnea and Actigraphy-Determined Sleep Duration in a Sample of the Hispanic Community Health Study/ Study of Latinos.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2019Article
- Increased augmentation index and central systolic arterial pressure are associated with lower school and motor performance in young adolescents.The Journal of international medical research · 2017Article
- Design of the ExCersion-VCI study: The effect of aerobic exercise on cerebral perfusion in patients with vascular cognitive impairment.Alzheimer's & dementia (New York, N. Y.) · 2017Article
- Hypoxia Inducible Factor 1α Promotes Endogenous Adaptive Response in Rat Model of Chronic Cerebral Hypoperfusion.International journal of molecular sciences · 2017Article
- The Missing Link in the Pathophysiology of Vascular Cognitive Impairment: Design of the Heart-Brain Study.Cerebrovascular diseases extra · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Vascular cognitive impairment has been traditionally defined by structural pathology, an accumulation of infarcts, leading to progressive cognitive decline. Recent evidence, however, suggests that cognitive impairment may be independently mediated by hemodynamic dysfunction, including global and hemispheral hypoperfusion and altered cerebral blood flow regulation. In this review, we examine evidence for the contribution of hemodynamic impairment to cognitive dysfunction in the setting of large vessel disease, cardiac failure, and microvascular disease. If there is a hemodynamic component of vascular cognitive impairment, then treatments proposed to correct impaired vascular physiology may reasonably be expected to treat the cognitive dysfunction as well.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.