ArticleEndocrine-related cancer2011
Gene expression signature discriminates sporadic from post-radiotherapy-induced thyroid tumors.
Article in Endocrine-related cancer, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Genetic alterations landscape in paediatric thyroid tumours and/or differentiated thyroid cancer: Systematic review.Reviews in endocrine & metabolic disorders · 2024Pooled it
- Iodine-131 dose dependent gene expression in thyroid cancers and corresponding normal tissues following the Chernobyl accident.PloS one · 2012Trial
- Post-Chornobyl thyroid papillary carcinomas display distinct pastScientific reports · 2026Article
- Consequences of atmospheric contamination by radioiodine: the Chernobyl and Fukushima accidents.Endocrine · 2021Review
- Matrix stiffness regulates myocardial differentiation of human umbilical cord mesenchymal stem cells.Aging · 2020Article
- Loss of stretch-activated channels, PIEZOs, accelerates non-small cell lung cancer progression and cell migration.Bioscience reports · 2019Article
- Review of risk factors of secondary cancers among cancer survivors.The British journal of radiology · 2019Review
- Gene expression profiling in undifferentiated thyroid carcinoma induced by high-dose radiation.Journal of radiation research · 2016Article
- Piezo channels: from structure to function.Pflugers Archiv : European journal of physiology · 2015Review
- Clinical, genetic, and immunohistochemical characterization of 70 Ukrainian adult cases with post-Chornobyl papillary thyroid carcinoma.European journal of endocrinology · 2012Article
- Article
- A transcriptome signature distinguished sporadic from postradiotherapy radiation-induced sarcomas.Carcinogenesis · 2011Article
- Strategy to find molecular signatures in a small series of rare cancers: validation for radiation-induced breast and thyroid tumors.PloS one · 2011Article
- Radiation exposure and thyroid cancer: a review.Archives of endocrinology and metabolismArticle
- Genetic predisposition to radiation-related cancer and potential implications for risk assessment.Annals of the ICRPArticle
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Both external and internal exposure to ionizing radiation are strong risk factors for the development of thyroid tumors. Until now, the diagnosis of radiation-induced thyroid tumors has been deduced from a network of arguments taken together with the individual history of radiation exposure. Neither the histological features nor the genetic alterations observed in these tumors have been shown to be specific fingerprints of an exposure to radiation. The aim of our work is to define ionizing radiation-related molecular specificities in a series of secondary thyroid tumors developed in the radiation field of patients treated by radiotherapy. To identify molecular markers that could represent a radiation-induction signature, we compared 25K microarray transcriptome profiles of a learning set of 28 thyroid tumors, which comprised 14 follicular thyroid adenomas (FTA) and 14 papillary thyroid carcinomas (PTC), either sporadic or consecutive to external radiotherapy in childhood. We identified a signature composed of 322 genes which discriminates radiation-induced tumors (FTA and PTC) from their sporadic counterparts. The robustness of this signature was further confirmed by blind case-by-case classification of an independent set of 29 tumors (16 FTA and 13 PTC). After the histology code break by the clinicians, 26/29 tumors were well classified regarding tumor etiology, 1 was undetermined, and 2 were misclassified. Our results help shed light on radiation-induced thyroid carcinogenesis, since specific molecular pathways are deregulated in radiation-induced tumors.
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