ArticleThe Journal of biological chemistry2011
Antimicrobial peptides increase tolerance to oxidant stress in Drosophila melanogaster.
Article in The Journal of biological chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 68 citations in OpenAlex.
- Article
- Evaluating the Impact of Vitamin DACS omega · 2024Article
- Cecropin A Alleviates LPS-Induced Oxidative Stress and Apoptosis of Bovine Endometrial Epithelial Cells.Animals : an open access journal from MDPI · 2024Article
- Investigating Sulforaphane's anti-virulence and anti-quorum sensing properties againstFrontiers in pharmacology · 2024Article
- Unraveling the Role of Antimicrobial Peptides in Insects.International journal of molecular sciences · 2023Review
- Heightened immune surveillance inHeliyon · 2022Article
- Vexed mutations promote degeneration of dopaminergic neurons through excessive activation of the innate immune response.NPJ Parkinson's disease · 2022Article
- RepurposingAntibiotics (Basel, Switzerland) · 2022Article
- Calycosin Alleviates Paraquat-Induced Neurodegeneration by Improving Mitochondrial Functions and Regulating Autophagy in aAntioxidants (Basel, Switzerland) · 2022Article
- Multiple mechanisms drive genomic adaptation to extreme ONature communications · 2021Article
- Amyloid-β peptides slightly affect lifespan or antimicrobial peptide gene expression in Drosophila melanogaster.BMC genetics · 2020Article
- Listening to your gut: immune challenge to the gut sensitizes body wall nociception in the caterpillarPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Article
- Cathelicidin attenuates hyperoxia-induced kidney injury in newborn rats.Renal failure · 2019Article
- A conserved role of the insulin-like signaling pathway in diet-dependent uric acid pathologies in Drosophila melanogaster.PLoS genetics · 2019Article
- The antimicrobial peptide defensin cooperates with tumour necrosis factor to drive tumour cell death ineLife · 2019Article
- Synergy and remarkable specificity of antimicrobial peptides in vivo using a systematic knockout approach.eLife · 2019Article
- Efflux pumps and antimicrobial resistance: Paradoxical components in systems genomics.Progress in biophysics and molecular biology · 2019Review
- The interplay between immunity and aging inF1000Research · 2018Review
- The bacterium Wolbachia exploits host innate immunity to establish a symbiotic relationship with the dengue vector mosquito Aedes aegypti.The ISME journal · 2018Article
- Mitotype Interacts With Diet to Influence Longevity, Fitness, and Mitochondrial Functions in Adult FemaleFrontiers in genetics · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
It is well appreciated that reactive oxygen species (ROS) are deleterious to mammals, including humans, especially when generated in abnormally large quantities from cellular metabolism. Whereas the mechanisms leading to the production of ROS are rather well delineated, the mechanisms underlying tissue susceptibility or tolerance to oxidant stress remain elusive. Through an experimental selection over many generations, we have previously generated Drosophila melanogaster flies that tolerate tremendous oxidant stress and have shown that the family of antimicrobial peptides (AMPs) is over-represented in these tolerant flies. Furthermore, we have also demonstrated that overexpression of even one AMP at a time (e.g. Diptericin) allows wild-type flies to survive much better in hyperoxia. In this study, we used a number of experimental approaches to investigate the potential mechanisms underlying hyperoxia tolerance in flies with AMP overexpression. We demonstrate that flies with Diptericin overexpression resist oxidative stress by increasing antioxidant enzyme activities and preventing an increase in ROS levels after hyperoxia. Depleting the GSH pool using buthionine sulfoximine limits fly survival, thus confirming that enhanced survival observed in these flies is related to improved redox homeostasis. We conclude that 1) AMPs play an important role in tolerance to oxidant stress, 2) overexpression of Diptericin changes the cellular redox balance between oxidant and antioxidant, and 3) this change in redox balance plays an important role in survival in hyperoxia.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.