ArticleMolecular biology of the cell2011
A meiotic gene regulatory cascade driven by alternative fates for newly synthesized transcripts.
Article in Molecular biology of the cell, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
- CDK Regulation of Meiosis: Lessons fromGenes · 2020Review
- A low-complexity region in the YTH domain protein Mmi1 enhances RNA binding.The Journal of biological chemistry · 2018Article
- Reconstitution of Targeted Deadenylation by the Ccr4-Not Complex and the YTH Domain Protein Mmi1.Cell reports · 2016Article
- Global intron retention mediated gene regulation during CD4+ T cell activation.Nucleic acids research · 2016Article
- BS69/ZMYND11 reads and connects histone H3.3 lysine 36 trimethylation-decorated chromatin to regulated pre-mRNA processing.Molecular cell · 2014Article
- Genome-wide analysis of poly(A) site selection in Schizosaccharomyces pombe.RNA (New York, N.Y.) · 2013Article
- Spliceosome-mediated decay (SMD) regulates expression of nonintronic genes in budding yeast.Genes & development · 2013Article
- Genome-wide mapping of polyadenylation sites in fission yeast reveals widespread alternative polyadenylation.RNA biology · 2013Article
- A dominant role for meiosis-specific 3' RNA processing in controlling expression of a fission yeast cyclin gene.RNA (New York, N.Y.) · 2012Article
- Coordinated regulation of neuronal mRNA steady-state levels through developmentally controlled intron retention.Genes & development · 2012Article
- New romance between RNA degradation pathways: Mmi1 and RNAi meet on heterochromatic islands.The EMBO journal · 2012Article
- Mmi1 RNA surveillance machinery directs RNAi complex RITS to specific meiotic genes in fission yeast.The EMBO journal · 2012Article
- Repression of meiotic genes by antisense transcription and by Fkh2 transcription factor in Schizosaccharomyces pombe.PloS one · 2012Article
- Programmed fluctuations in sense/antisense transcript ratios drive sexual differentiation in S. pombe.Molecular systems biology · 2011Article
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Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
To determine the relative importance of transcriptional regulation versus RNA processing and turnover during the transition from proliferation to meiotic differentiation in the fission yeast Schizosaccharomyces pombe, we analyzed temporal profiles and effects of RNA surveillance factor mutants on expression of 32 meiotic genes. A comparison of nascent transcription with steady-state RNA accumulation reveals that the vast majority of these genes show a lag between maximal RNA synthesis and peak RNA accumulation. During meiosis, total RNA levels parallel 3' processing, which occurs in multiple, temporally distinct waves that peak from 3 to 6 h after meiotic induction. Most early genes and one middle gene, mei4, share a regulatory mechanism in which a specialized RNA surveillance factor targets newly synthesized transcripts for destruction. Mei4p, a member of the forkhead transcription factor family, in turn regulates a host of downstream genes. Remarkably, a spike in transcription is observed for less than one-third of the genes surveyed, and even these show evidence of RNA-level regulation. In aggregate, our findings lead us to propose that a regulatory cascade driven by changes in processing and stability of newly synthesized transcripts operates alongside the well-known transcriptional cascade as fission yeast cells enter meiosis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.