ArticleMolecular biology and evolution2011
Expansion of voltage-dependent Na+ channel gene family in early tetrapods coincided with the emergence of terrestriality and increased brain complexity.
Article in Molecular biology and evolution, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Voltage-gated ion channel diversity underlies neuronal excitability and nervous system evolution.Nature communications · 2025Article
- Characterization of NaLife science alliance · 2024Article
- Divergent cis-regulatory evolution underlies the convergent loss of sodium channel expression in electric fish.Science advances · 2022Article
- Gene Conversion Facilitates the Adaptive Evolution of Self-Resistance in Highly Toxic Newts.Molecular biology and evolution · 2021Article
- Genome Analysis ofFrontiers in genetics · 2021Article
- Sodium action potentials in placozoa: Insights into behavioral integration and evolution of nerveless animals.Biochemical and biophysical research communications · 2020Article
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- Ancestral reconstruction of protein interaction networks.PLoS computational biology · 2019Article
- Genomic Takeover by Transposable Elements in the Strawberry Poison Frog.Molecular biology and evolution · 2018Article
- Molecular Adaptations for Sensing and Securing Prey and Insight into Amniote Genome Diversity from the Garter Snake Genome.Genome biology and evolution · 2018Article
- Cross-kingdom auxiliary subunit modulation of a voltage-gated sodium channel.The Journal of biological chemistry · 2018Article
- Article
- Voltage-gated sodium channel gene repertoire of lampreys: gene duplications, tissue-specific expression and discovery of a long-lost gene.Proceedings. Biological sciences · 2017Article
- Kiwi genome provides insights into evolution of a nocturnal lifestyle.Genome biology · 2015Article
- Evolutionary history of a complex adaptation: tetrodotoxin resistance in salamanders.Evolution; international journal of organic evolution · 2015Article
- Parallel evolution of tetrodotoxin resistance in three voltage-gated sodium channel genes in the garter snake Thamnophis sirtalis.Molecular biology and evolution · 2014Article
- A novel de novo mutation of SCN8A (Nav1.6) with enhanced channel activation in a child with epileptic encephalopathy.Neurobiology of disease · 2014Article
- Molecular identity of axonal sodium channels in human cortical pyramidal cells.Frontiers in cellular neuroscience · 2014Article
- Sodium channel SCN8A (Nav1.6): properties and de novo mutations in epileptic encephalopathy and intellectual disability.Frontiers in genetics · 2013Review
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3 authors.
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Abstract
Mammals have ten voltage-dependent sodium (Nav) channel genes. Nav channels are expressed in different cell types with different subcellular distributions and are critical for many aspects of neuronal processing. The last common ancestor of teleosts and tetrapods had four Nav channel genes, presumably on four different chromosomes. In the lineage leading to mammals, a series of tandem duplications on two of these chromosomes more than doubled the number of Nav channel genes. It is unknown when these duplications occurred and whether they occurred against a backdrop of duplication of flanking genes on their chromosomes or as an expansion of ion channel genes in general. We estimated key dates of the Nav channel gene family expansion by phylogenetic analysis using teleost, elasmobranch, lungfish, amphibian, avian, lizard, and mammalian Nav channel sequences, as well as chromosomal synteny for tetrapod genes. We tested, and exclude, the null hypothesis that Nav channel genes reside in regions of chromosomes prone to duplication by demonstrating the lack of duplication or duplicate retention of surrounding genes. We also find no comparable expansion in other voltage-dependent ion channel gene families of tetrapods following the teleost-tetrapod divergence. We posit a specific expansion of the Nav channel gene family in the Devonian and Carboniferous periods when tetrapods evolved, diversified, and invaded the terrestrial habitat. During this time, the amniote forebrain evolved greater anatomical complexity and novel tactile sensory receptors appeared. The duplication of Nav channel genes allowed for greater regional specialization in Nav channel expression, variation in subcellular localization, and enhanced processing of somatosensory input.
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