ArticleMicrobiology (Reading, England)2011
clpB, a class III heat-shock gene regulated by CtsR, is involved in thermotolerance and virulence of Enterococcus faecalis.
Article in Microbiology (Reading, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed.
- Heat Shock Protein 104 (Genes · 2025Article
- Identification of ClpB, a molecular chaperone involved in the stress tolerance and virulence of Streptococcus agalactiae.Veterinary research · 2024Article
- Antibacterial Property and Mechanisms of Au@Ag Core-Shell Nanoparticles with Near-Infrared Absorption AgainstInternational journal of nanomedicine · 2024Article
- Hsp100 Molecular Chaperone ClpB and Its Role in Virulence of Bacterial Pathogens.International journal of molecular sciences · 2021Review
- The Role of ClpB in Bacterial Stress Responses and Virulence.Frontiers in molecular biosciences · 2021Review
- Effects of ClpP protease on biofilm formation of Enterococcus faecalis.Journal of applied oral science : revista FOB · 2021Article
- Upregulation of the clpB gene in response to heat shock and beta-lactam antibiotics in Acinetobacter baumannii.Molecular biology reports · 2020Article
- Adaptation to Adversity: the Intermingling of Stress Tolerance and Pathogenesis in Enterococci.Microbiology and molecular biology reviews : MMBR · 2019Review
- The amino-terminal domain ofFEBS open bio · 2018Article
- Stand-alone ClpG disaggregase confers superior heat tolerance to bacteria.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Protein aggregation in Ehrlichia chaffeensis during infection of mammalian cells.FEMS microbiology letters · 2017Article
- Stress Physiology of Lactic Acid Bacteria.Microbiology and molecular biology reviews : MMBR · 2016Review
- Galleria mellonella infection models for the study of bacterial diseases and for antimicrobial drug testing.Virulence · 2016Review
- Simultaneous Host-Pathogen Transcriptome Analysis during Granulibacter bethesdensis Infection of Neutrophils from Healthy Subjects and Patients with Chronic Granulomatous Disease.Infection and immunity · 2015Article
- The Intraperitoneal Transcriptome of the Opportunistic Pathogen Enterococcus faecalis in Mice.PloS one · 2015Article
- Enterococcus infection biology: lessons from invertebrate host models.Journal of microbiology (Seoul, Korea) · 2014Review
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- Thermal control of virulence factors in bacteria: a hot topic.Virulence · 2014Review
- Aggregate-reactivation activity of the molecular chaperone ClpB from Ehrlichia chaffeensis.PloS one · 2013Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Here, we transcriptionally and phenotypically characterized the clpB gene from Enterococcus faecalis. Northern blot analysis identified a monocistronic mRNA strongly induced at 48 and 50 °C. In silico analysis identified that the clpB gene encodes a protein of 868 aa with a predicted molecular mass of approximately 98 kDa, presenting two conserved ATP-binding domains. Sequence analysis also identified a CtsR-binding box upstream of the putative -10 sequence, and inactivation of the ctsR gene resulted in an approximately 2-log increase in clpB mRNA expression, confirming ClpB as a member of the CtsR regulon. While expression of clpB was induced by heat stress, a ΔclpB strain grew relatively well under many different stressful conditions, including elevated temperatures. However, expression of ClpB appears to play a major role in induced thermotolerance and in pathogenesis, as assessed by using the Galleria mellonella virulence model.
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