ArticleBiology of reproduction2011
Generation of viable male and female mice from two fathers.
Article in Biology of reproduction, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Assisted same-sex conception: reproduction reimagined.F&S reports · 2024Article
- Review
- Article
- Live births from urine derived cells.PloS one · 2023Article
- Giant Island Mice Exhibit Widespread Gene Expression Changes in Key Metabolic Organs.Genome biology and evolution · 2020Article
- "I am Your Mother and Your Father!" In Vitro Derived Gametes and the Ethics of Solo Reproduction.Health care analysis : HCA : journal of health philosophy and policy · 2017Article
- Generation of electrophysiologically functional cardiomyocytes from mouse induced pluripotent stem cells.Stem cell research · 2016Article
- Will artificial gametes end infertility?Health care analysis : HCA : journal of health philosophy and policy · 2015Article
- Article
- Rapid selection of XO embryonic stem cells using Y chromosome-linked GFP transgenic mice.Transgenic research · 2014Article
- Artificial gametes: perspectives of geneticists, ethicists and representatives of potential users.Medicine, health care, and philosophy · 2014Article
- Induced multipotency in adult keratinocytes through down-regulation of ΔNp63 or DGCR8.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
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Authors and funding
8 authors.
Funding
Abstract
In sexual species, fertilization of oocytes produces individuals with alleles derived from both parents. Here we use pluripotent stem cells derived from somatic cells to combine the haploid genomes from two males to produce viable sons and daughters. Male (XY) mouse induced pluripotent stem cells (Father #1) were used to isolate subclones that had spontaneously lost the Y chromosome to become genetically female (XO). These male-derived XO stem cells were used to generate female chimeras that were bred with genetically distinct males (Father #2), yielding progeny possessing genetic information that was equally derived from both fathers. Thus, functional oocytes can be generated from male somatic cells after reprogramming and spontaneous sex reversal. These findings have novel implications for mammalian reproduction and assisted reproductive technology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.