ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
Dependence of serotonergic and other nonadrenergic enteric neurons on norepinephrine transporter expression.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 43 citations in OpenAlex.
- Functional role of the enteric nervous system in poultry intestinal health and production.Poultry science · 2026Review
- Molecular and functional diversity of the autonomic nervous system.Nature reviews. Neuroscience · 2025Review
- Cocaine hydrochloride, cocaine methiodide and methylenedioxypyrovalerone (MDPV) cause distinct alterations in the structure and composition of the gut microbiota.Scientific reports · 2023Article
- Gut colonization by Proteobacteria alters host metabolism and modulates cocaine neurobehavioral responses.Cell host & microbe · 2022Article
- Hypothalamic detection of macronutrients via multiple gut-brain pathways.Cell metabolism · 2021Article
- Differential effects of synthetic psychoactive cathinones and amphetamine stimulants on the gut microbiome in mice.PloS one · 2020Article
- Monoamines in the enteric nervous system.Histochemistry and cell biology · 2018Review
- B2 adrenergic receptors and morphological changes of the enteric nervous system in colorectal adenocarcinoma.World journal of gastroenterology · 2017Observational
- Mouse models of Hirschsprung disease and other developmental disorders of the enteric nervous system: Old and new players.Developmental biology · 2016Review
- Gene-environment interactions and the enteric nervous system: Neural plasticity and Hirschsprung disease prevention.Developmental biology · 2016Review
- Involvement of catecholaminergic neurons in motor innervation of striated muscle in the mouse esophagus.Histochemistry and cell biology · 2016Article
- Article
- Changes in Nicotinic Neurotransmission during Enteric Nervous System Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Building a second brain in the bowel.The Journal of clinical investigation · 2015Review
- Birthdating of myenteric neuron subtypes in the small intestine of the mouse.The Journal of comparative neurology · 2014Article
- Balancing on the crest - Evidence for disruption of the enteric ganglia via inappropriate lineage segregation and consequences for gastrointestinal function.Developmental biology · 2013Review
- Enteric nervous system development: migration, differentiation, and disease.American journal of physiology. Gastrointestinal and liver physiology · 2013Review
- Choices choices: regulation of precursor differentiation during enteric nervous system development.Neurogastroenterology and motility · 2013Review
- Development and developmental disorders of the enteric nervous system.Nature reviews. Gastroenterology & hepatology · 2013Review
- Duodenal calcium transporter mRNA expression in stressed male rats treated with diazepam, fluoxetine, reboxetine, or venlafaxine.Molecular and cellular biochemistry · 2012Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
The norepinephrine transporter (NET), which is expressed on the plasma membranes of noradrenergic neurons, is important in terminating neurotransmission. The noradrenergic sympathetic neurons that innervate the bowel express NET, but they are extrinsic and their cell bodies are not components of the enteric nervous system (ENS). Subsets of neurons were nevertheless found in the murine ENS that express transcripts encoding NET, NET protein, and dopamine β-hydroxylase; these neurons lack tyrosine hydroxylase (TH) and thus are not catecholaminergic. Enteric NET expression, moreover, preceded the ingrowth of sympathetic axons during development and did not disappear when the gut was extrinsically denervated. Transiently catecholaminergic (TC), neural crest-derived precursors of enteric neurons expressed NET at embryonic day 10 (E10) and NET expression in the fetal gut peaked coincidentally with early neurogenesis at E12. Serotonergic neurons, which are born early from TC progenitors, were found to express NET in the adult ENS, as did also other early-born neurons containing calretinin or neuronal nitric oxide synthase (nNOS) immunoreactivities. NET was not expressed in TH-immunoreactive dopaminergic neurons, which are born perinatally. Genetic deletion of NET almost eliminated tryptophan hydroxylase 2 expression and significantly reduced the numbers of total, 5-HT- and calretinin-immunoreactive enteric neurons, without affecting the immunoreactivities of nNOS or TH. These observations indicate that TC precursors of subsets of noncatecholaminergic enteric neurons express NET that persists in the successors of these cells despite their loss of TH. NET expression is essential for development and/or survival of some (5-HT- and calretinin-expressing), but not all (nNOS-expressing), of these neurons.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.