ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
A refractory period for rejuvenating GABAergic synaptic transmission and ocular dominance plasticity with dark exposure.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 67 citations in OpenAlex.
- Anodal transcranial direct current stimulation reduces psychophysically measured surround suppression in the human visual cortex.PloS one · 2012Trial
- Tuning excitatory input to fast-spiking parvalbumin-positive interneurons: a lever for plasticity and hyperexcitability across the lifespan.Frontiers in synaptic neuroscience · 2026Article
- The Influence of Changes in Microglia Development on the Plasticity of the Developing Visual Cortex Circuit in Juvenile Mice.Investigative ophthalmology & visual science · 2025Article
- Selective plasticity of fast and slow excitatory synapses on somatostatin interneurons in adult visual cortex.Nature communications · 2023Article
- Circadian time- and sleep-dependent modulation of cortical parvalbumin-positive inhibitory neurons.The EMBO journal · 2023Article
- Article
- Retinoid therapy restores eye-specific cortical responses in adult mice with retinal degeneration.Current biology : CB · 2022Article
- Visual Deprivation Selectively Reduces Thalamic Reticular Nucleus-Mediated Inhibition of the Auditory Thalamus in Adults.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Perspectives on the Combined Use of Electric Brain Stimulation and Perceptual Learning in Vision.Vision (Basel, Switzerland) · 2022Article
- Pull-push neuromodulation of cortical plasticity enables rapid bi-directional shifts in ocular dominance.eLife · 2020Article
- Silent Synapse-Based Mechanisms of Critical Period Plasticity.Frontiers in cellular neuroscience · 2020Review
- Modification of Peak Plasticity Induced by Brief Dark Exposure.Neural plasticity · 2019Article
- Transient and localized optogenetic activation of somatostatin-interneurons in mouse visual cortex abolishes long-term cortical plasticity due to vision loss.Brain structure & function · 2018Article
- Amblyopia: New molecular/pharmacological and environmental approaches.Visual neuroscience · 2018Review
- Critical periods in amblyopia.Visual neuroscience · 2018Review
- Chondroitin Sulfate Is Required for Onset and Offset of Critical Period Plasticity in Visual Cortex.Scientific reports · 2017Article
- Article
- Noise Trauma-Induced Behavioral Gap Detection Deficits Correlate with Reorganization of Excitatory and Inhibitory Local Circuits in the Inferior Colliculus and Are Prevented by Acoustic Enrichment.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Integrating Hebbian and homeostatic plasticity: introduction.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Article
- Experience-dependent homeostasis of 'noise' at inhibitory synapses preserves information coding in adult visual cortex.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Dark exposure initiated in adulthood reactivates robust ocular dominance plasticity in the visual cortex. Here, we show that a critical component of the response to dark exposure is the rejuvenation of inhibitory synaptic transmission, resulting in a decrease in functional inhibitory synaptic density, a decrease in paired-pulse depression, and a reexpression of endocannabinoid-dependent inhibitory long-term depression (iLTD). Importantly, pharmacological acceleration of the maturation of inhibition in dark-exposed adults inhibits the reexpression of iLTD and the reactivation of ocular dominance plasticity. Surprisingly, dark exposure initiated earlier in postnatal development does not rejuvenate inhibitory synaptic transmission or facilitate rapid ocular dominance plasticity, demonstrating the presence of a refractory period for the regulation of synaptic plasticity by visual deprivation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.