ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
Involvement of the thalamic parafascicular nucleus in mesial temporal lobe epilepsy.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 59 citations in OpenAlex.
- Article
- Comorbidities in the mouse model of temporal lobe epilepsy induced by intrahippocampal kainate.Epilepsia · 2025Article
- Thalamic nuclei volumes and intrinsic thalamic network in patients with occipital lobe epilepsy.Brain and behavior · 2023Article
- Aberrant survival of hippocampal Cajal-Retzius cells leads to memory deficits, gamma rhythmopathies and susceptibility to seizures in adult mice.Nature communications · 2023Article
- Article
- The intralaminar thalamus: a review of its role as a target in functional neurosurgery.Brain communications · 2023Review
- The current approach of the Epilepsy Therapy Screening Program contract site for identifying improved therapies for the treatment of pharmacoresistant seizures in epilepsy.Neuropharmacology · 2020Review
- A disinhibitory nigra-parafascicular pathway amplifies seizure in temporal lobe epilepsy.Nature communications · 2020Article
- Quantification of thalamic nuclei in patients diagnosed with temporal lobe epilepsy and hippocampal sclerosis.Neuroradiology · 2020Observational
- The paroxysmal depolarization shift in epilepsy research.The international journal of biochemistry & cell biology · 2019Review
- A Transgenic Mouse Model to Selectively Identify αNeuroscience · 2019Article
- Electrophysiological Evidence for the Development of a Self-Sustained Large-Scale Epileptic Network in the Kainate Mouse Model of Temporal Lobe Epilepsy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Evaluation of Cannabidiol in Animal Seizure Models by the Epilepsy Therapy Screening Program (ETSP).Neurochemical research · 2017Article
- Differential Effects of Antiepileptic Drugs on Focal Seizures in the Intrahippocampal Kainate Mouse Model of Mesial Temporal Lobe Epilepsy.CNS neuroscience & therapeutics · 2016Article
- Does the Thalamo-Cortical Synchrony Play a Role in Seizure Termination?Frontiers in neurology · 2015Article
- Anterior Cingulate epilepsy: mechanisms and modulation.Frontiers in integrative neuroscience · 2014Review
- Involvement of thalamus in initiation of epileptic seizures induced by pilocarpine in mice.Neural plasticity · 2014Article
- Mapping epileptic activity: sources or networks for the clinicians?Frontiers in neurology · 2014Review
- Centromedian-parafascicular deep brain stimulation induces differential functional inhibition of the motor, associative, and limbic circuits in large animals.Biological psychiatry · 2013Article
- Neurobehavioral comorbidities of pediatric epilepsies are linked to thalamic structural abnormalities.Epilepsia · 2013Article
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mesial temporal lobe epilepsy (MTLE) is characterized by focal seizures, associated with hippocampal sclerosis, and often resistance to antiepileptic drugs. The parafascicular nucleus (PF) of the thalamus is involved in the generation of physiological oscillatory rhythms. It receives excitatory inputs from the cortex and inhibitory inputs from the basal ganglia, a system implicated in the control of epileptic seizures. The aim of this study was to examine the involvement of the PF in the occurrence of hippocampal paroxysmal discharges (HPDs) in a chronic animal model of MTLE in male mice. We recorded the local field potential (LFP) and the extracellular and intracellular activity of hippocampal and PF neurons during spontaneous HPDs in vivo. The end of the HPDs was concomitant with a slow repolarization in hippocampal neurons leading to an electrical silence. In contrast, it was associated in the PF with a transient increase in the power of the 10-20 Hz band in LFPs and a depolarization of PF neurons resulting in a sustained firing. We tested the role of the PF in the control of HPDs by single 130 Hz electrical stimulation of this nucleus and bilateral intra-PF injection of NMDA and GABA(A) antagonist and agonist. High-frequency PF stimulation interrupted ongoing HPDs at an intensity devoid of behavioral effects. NMDA antagonist and GABA(A) agonist suppressed hippocampal discharges in a dose-dependent way, whereas NMDA agonist and GABA(A) antagonist increased HPDs. Altogether, these data suggest that the PF nucleus plays a role in the modulation of MTLE seizures.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.