ArticleJournal of clinical microbiology2011
Complete genome analysis of a novel intertypic recombinant human adenovirus causing epidemic keratoconjunctivitis in Japan.
Article in Journal of clinical microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 60 citations in OpenAlex.
- Evaluation of factors relating to the development of multiple subepithelial corneal infiltrates of adenoviral keratoconjunctivitis using categorical data analysis program.Japanese journal of ophthalmology · 2025Article
- Isolation of a recombinant simian adenovirus encoding the human adenovirus G52 hexon suggests a simian origin for human adenovirus G52.Journal of virology · 2024Article
- Respiratory virus infections and adenovirus characteristics during acute exacerbation of chronic obstructive pulmonary disease.Technology and health care : official journal of the European Society for Engineering and Medicine · 2024Article
- Characterization of Human Adenoviruses of Medical Importance: Isolation of Infectious Virus from Clinical Specimens and Molecular Typing.Current protocols · 2023Article
- Article
- Characteristic of slow growth in cell culture of adenovirus type 54 causing nationwide outbreak epidemic keratoconjunctivitis in Japan.Japanese journal of ophthalmology · 2020Article
- Mystery eye: Human adenovirus and the enigma of epidemic keratoconjunctivitis.Progress in retinal and eye research · 2020Review
- Genomic foundations of evolution and ocular pathogenesis in human adenovirus species D.FEBS letters · 2019Review
- An outbreak of epidemic keratoconjunctivitis caused by human adenovirus type 8 in primary school, southwest China.BMC infectious diseases · 2019Article
- Infectious human adenoviruses are shed in urine even after disappearance of urethral symptoms.PloS one · 2019Article
- Genomic analysis of a large set of currently-and historically-important human adenovirus pathogens.Emerging microbes & infections · 2018Article
- Comparative genomic analysis of two emergent human adenovirus type 14 respiratory pathogen isolates in China reveals similar yet divergent genomes.Emerging microbes & infections · 2017Article
- Identification of Human Adenovirus in Respiratory Samples with Luminex Respiratory Virus Panel Fast V2 Assay and Real-Time Polymerase Chain Reaction.International journal of molecular sciences · 2016Article
- Recombination of the epsilon determinant and corneal tropism: Human adenovirus species D types 15, 29, 56, and 69.Virology · 2015Article
- Identification of a novel intertypic recombinant species D human adenovirus in a pediatric stem cell transplant recipient.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2014Article
- Human adenovirus: Viral pathogen with increasing importance.European journal of microbiology & immunology · 2014Article
- Antiadenoviral effects of ganciclovir in types inducing keratoconjunctivitis by quantitative polymerase chain reaction methods.Clinical ophthalmology (Auckland, N.Z.) · 2014Article
- Outbreak of epidemic keratoconjunctivitis caused by human adenovirus type 56, China, 2012.PloS one · 2014Article
- Anti-adenoviral effects of human cationic antimicrobial protein-18/LL-37, an antimicrobial peptide, by quantitative polymerase chain reaction.Korean journal of ophthalmology : KJO · 2013Article
- Overreliance on the hexon gene, leading to misclassification of human adenoviruses.Journal of virology · 2012Article
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
For 4 months from September 2008, 102 conjunctival swab specimens were collected for surveillance purposes from patients across Japan suspected of having epidemic keratoconjunctivitis (EKC). Human adenovirus (HAdV) DNA was detected in 61 samples by PCR, though the HAdV type for 6 of the PCR-positive samples could not be determined by phylogenetic analysis using a partial hexon gene sequence. Moreover, for 2 months from January 2009, HAdV strains with identical sequences were isolated from five conjunctival swab samples obtained from EKC patients in five different regions of Japan. For the analyses of the 11 samples mentioned above, we determined the nucleotide sequences of the entire penton base, hexon, and fiber genes and early 3 (E3) region, which are variable regions among HAdV types, and compared them to those of other HAdV species D strains. The nucleotide sequences of loops 1 and 2 in the hexons of all 11 samples showed high degrees of identity with those of the HAdV type 15 (HAdV-15) and HAdV-29 prototype strains. However, the fiber gene and E3 region sequences showed high degrees of identity with those of HAdV-9, and the penton base gene sequence showed a high degree of identity with the penton base gene sequences of HAdV-9 and -26. Moreover, the complete genome sequence of the 2307-S strain, which was isolated by viral culture from 1 of the 11 samples, was determined. The 2307-S strain was a recombinant HAdV between HAdV-9, -15, -26, -29, and/or another HAdV type; however, the recombination sites in the genome were not obvious. We propose that this virus is a novel intertypic recombinant, HAdV-15/29/H9, and may be an etiological agent of EKC.
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