ArticleGenome research2011
High-throughput sequencing of complete human mtDNA genomes from the Philippines.
Article in Genome research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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Who cites it
61 citing papers in PubMed.
- Distinct age-related pattern of mitochondrial somatic mutations across multiple sclerosis phenotypes.Journal of neurology · 2026Article
- Demographic History of Indigenous Populations in Mexico Explored Through Whole Mitogenome Analysis.Genome biology and evolution · 2026Article
- Genetic insights into the origin, admixture, and migration of the early Austronesian peoples.Journal of human genetics · 2026Review
- Genomic evidence supports the "long chronology" for the peopling of Sahul.Science advances · 2025Article
- Article
- Investigating demic versus cultural diffusion and sex bias in the spread of Austronesian languages in Vietnam.PloS one · 2024Article
- Review
- Diversity and distribution of mitochondrial DNA in non-Austronesian-speaking Taiwanese individuals.Human genome variation · 2023Article
- South Asian maternal and paternal lineages in southern Thailand and the role of sex-biased admixture.PloS one · 2023Article
- Ethical challenges in genetic research among Philippine Indigenous Peoples: Insights from fieldwork in Zamboanga and the Sulu Archipelago.Frontiers in genetics · 2022Article
- Mitochondrial genome sequencing with short overlapping amplicons on MiSeq FGx system.Forensic sciences research · 2022Article
- Genome-scale sequencing and analysis of human, wolf, and bison DNA from 25,000-year-old sediment.Current biology : CB · 2021Article
- Massive parallel sequencing in forensics: advantages, issues, technicalities, and prospects.International journal of legal medicine · 2020Review
- Whole Mitochondrial DNA Sequencing Analysis in 47 Han Populations in Southwest China.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- How many individuals share a mitochondrial genome?PLoS genetics · 2018Article
- Complete human mtDNA genome sequences from Vietnam and the phylogeography of Mainland Southeast Asia.Scientific reports · 2018Article
- Carriers of mitochondrial DNA macrohaplogroup L3 basal lineages migrated back to Africa from Asia around 70,000 years ago.BMC evolutionary biology · 2018Article
- Contrasting maternal and paternal genetic variation of hunter-gatherer groups in Thailand.Scientific reports · 2018Article
- Carriers of mitochondrial DNA macrohaplogroup R colonized Eurasia and Australasia from a southeast Asia core area.BMC evolutionary biology · 2017Article
- Complete mitochondrial genomes of Thai and Lao populations indicate an ancient origin of Austroasiatic groups and demic diffusion in the spread of Tai-Kadai languages.Human genetics · 2017Article
1 more citing papers are in PubMed but not listed here.
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5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Because of the time and cost associated with Sanger sequencing of complete human mtDNA genomes, practically all evolutionary studies have screened samples first to define haplogroups and then either selected a few samples from each haplogroup, or many samples from a particular haplogroup of interest, for complete mtDNA genome sequencing. Such biased sampling precludes many analyses of interest. Here, we used high-throughput sequencing platforms to generate, rapidly and inexpensively, 109 complete mtDNA genome sequences from random samples of individuals from three Filipino groups, including one Negrito group, the Mamanwa. We obtained on average ∼55-fold coverage per sequence, with <1% missing data per sequence. Various analyses attest to the accuracy of the sequences, including comparison to sequences of the first hypervariable segment of the control region generated by Sanger sequencing; patterns of nucleotide substitution and the distribution of polymorphic sites across the genome; and the observed haplogroups. Bayesian skyline plots of population size change through time indicate similar patterns for all three Filipino groups, but sharply contrast with such plots previously constructed from biased sampling of complete mtDNA genomes, as well as with an artificially constructed sample of sequences that mimics the biased sampling. Our results clearly demonstrate that the high-throughput sequencing platforms are the methodology of choice for generating complete mtDNA genome sequences.
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