ArticleMolecular endocrinology (Baltimore, Md.)2011
Luteinizing hormone receptor mRNA down-regulation is mediated through ERK-dependent induction of RNA binding protein.
Article in Molecular endocrinology (Baltimore, Md.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 42 citations in OpenAlex.
- A Novel Steroidogenic Action of Anti-Müllerian Hormone in Teleosts: Evidence from the European Sea Bass Male (International journal of molecular sciences · 2025Article
- Pharmacogenomic of LH and its receptor: are we ready for clinical practice?Reproductive biology and endocrinology : RB&E · 2025Review
- Short-Term Exposure to Bisphenol A Does Not Impact Gonadal Cell Steroidogenesis In Vitro.Cells · 2023Article
- Hypogonadism induced by surgical stress and brain trauma is reversed by human chorionic gonadotropin in male rats: A potential therapy for surgical and TBI-induced hypogonadism?Endocrinology, diabetes & metabolism · 2021Article
- The mRNA-destabilizing protein Tristetraprolin targets "meiosis arrester"Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Association between LH receptor regulation and ovarian hyperstimulation syndrome in a rodent model.Reproduction (Cambridge, England) · 2020Article
- SREBP Plays a Regulatory Role in LH/hCG Receptor mRNA Expression in Human Granulosa-Lutein Cells.The Journal of clinical endocrinology and metabolism · 2019Article
- miR-122 Regulates LHR Expression in Rat Granulosa Cells by Targeting Insig1 mRNA.Endocrinology · 2018Article
- Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways.Experimental & molecular medicine · 2018Review
- Regulation of Luteinizing Hormone Receptor mRNA Expression in the Ovary: The Role of miR-122.Vitamins and hormones · 2018Review
- LHCGR Expression During Follicle Stimulating Hormone-Induced Follicle Growth Is Negatively Regulated by Eukaryotic Initiation Factor 5A.Endocrinology · 2017Article
- Molecular regulation of LHCGR expression by miR-122 during follicle growth in the rat ovary.Molecular and cellular endocrinology · 2017Article
- Hypusination of eukaryotic initiation factor 5A via cAMP-PKA-ERK1/2 pathway is required for ligand-induced downregulation of LH receptor mRNA expression in the ovary.Molecular and cellular endocrinology · 2015Article
- miR-122 Regulates LH Receptor Expression by Activating Sterol Response Element Binding Protein in Rat Ovaries.Endocrinology · 2015Article
- Controlled Ovarian Stimulation with recombinant-FSH plus recombinant-LH vs. human Menopausal Gonadotropin based on the number of retrieved oocytes: results from a routine clinical practice in a real-life population.Reproductive biology and endocrinology : RB&E · 2015Article
- Regulation of luteinizing hormone receptor expression by an RNA binding protein: role of ERK signaling.The Indian journal of medical research · 2014Review
- Eukaryotic initiation factor 5A plays an essential role in luteinizing hormone receptor regulation.Molecular endocrinology (Baltimore, Md.) · 2014Article
- Regulation of LH receptor mRNA binding protein by miR-122 in rat ovaries.Endocrinology · 2013Article
- Association of luteinizing hormone receptor (LHR) mRNA with its binding protein leads to decapping and degradation of the mRNA in the p bodies.Biochimica et biophysica acta · 2013Article
- Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The ligand-induced down-regulation of LH receptor (LHR) expression in the ovaries, at least in part, is regulated by a posttranscriptional process mediated by a specific LH receptor mRNA binding protein (LRBP). The LH-mediated signaling pathways involved in this process were examined in primary cultures of human granulosa cells. Treatment with 10 IU human chorionic gonadotropin (hCG) for 12 h resulted in the down-regulation of LHR mRNA expression while producing an increase in LHR mRNA binding to LRBP as well as a 2-fold increase in LRBP levels. The activation of ERK1/2 pathway in LH-mediated LHR mRNA down-regulation was also established by demonstrating the translocation of ERK1/2 from the cytosol to the nucleus using confocal microcopy. Inhibition of protein kinase A using H-89 or ERK1/2 by U0126 abolished the LH-induced LHR mRNA down-regulation. These treatments also abrogated both the increases in LRBP levels as well as the LHR mRNA binding activity. The abolishment of the hCG-induced increase in LRBP levels and LHR mRNA binding activity was further confirmed by transfecting granulosa cells with ERK1/2 specific small interfering RNA. This treatment also reversed the hCG-induced down-regulation of LHR mRNA. These data show that LH-regulated ERK1/2 signaling is required for the LRBP-mediated down-regulation of LHR mRNA.
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Registered trials
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