ArticleProceedings. Biological sciences2011
MAOA-L carriers are better at making optimal financial decisions under risk.
Article in Proceedings. Biological sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The Genetics of Risk Aversion: A Systematic Review.International journal of environmental research and public health · 2022Pooled it
- Delayed reward discounting and addictive behavior: a meta-analysis.Psychopharmacology · 2011Pooled it
- The Positive Modulation Effect of a 6-Week Consumption of an Anthocyanin-Rich Mulberry Milk on Working Memory, Cholinergic, and Monoaminergic Functions in Healthy Working-Age Adults.Oxidative medicine and cellular longevity · 2021Trial
- Blunted insula activation reflects increased risk and reward seeking as an interaction of testosterone administration and the MAOA polymorphism.Human brain mapping · 2017Trial
- Dopaminergic Modulation of Decision Making and Subjective Well-Being.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Trial
- Intracranial recordings in humans reveal differential contributions of medial and lateral orbitofrontal cortex to approach-avoidance decision-making.Nature neuroscience · 2026Article
- Insights into neuroscience from the representative birth cohort samples of a multidisciplinary longitudinal study.Acta neuropsychiatrica · 2026Review
- Balancing Risk and Reward: Dopamine's Central Role in Economic Decision-Making.Brain sciences · 2025Review
- Higher alcohol use is associated with subsequent increased risk seeking toward gains: A longitudinal cohort study in young men.Alcohol, clinical & experimental research · 2025Article
- Differential susceptibility effects of theFrontiers in psychiatry · 2025Article
- MAOA methylation is associated with impulsive and antisocial behaviour: dependence on allelic variation, family environment and diet.Journal of neural transmission (Vienna, Austria : 1996) · 2024Article
- The effect of the 7R allele at the DRD4 locus on risk tolerance is independent of background risk in Senegalese fishermen.Scientific reports · 2023Article
- Reduced learning bias towards the reward context in medication-naive first-episode schizophrenia patients.BMC psychiatry · 2022Article
- Reward-specific satiety affects subjective value signals in orbitofrontal cortex during multicomponent economic choice.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Connectivity adaptations in dopaminergic systems define the brain maturity of investors.Scientific reports · 2021Article
- Motor cortical thickness is related to effort-based decision-making in humans.Journal of neurophysiology · 2020Article
- Roles of Ventromedial Prefrontal Cortex and Anterior Cingulate in Subjective Valuation of Prospective Effort.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Endogenous fluctuations in the dopaminergic midbrain drive behavioral choice variability.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Context-dependent sensitivity to losses: Range and skew manipulations.Journal of experimental psychology. Learning, memory, and cognition · 2019Article
- Motor Cortex Excitability Reflects the Subjective Value of Reward and Mediates Its Effects on Incentive-Motivated Performance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genes can affect behaviour towards risks through at least two distinct neurocomputational mechanisms: they may affect the value assigned to different risky options, or they may affect the way in which the brain adjudicates between options based on their value. We combined methods from neuroeconomics and behavioural genetics to investigate the impact that the genes encoding for monoamine oxidase-A (MAOA), the serotonin transporter (5-HTT) and the dopamine D4 receptor (DRD4) have on these two computations. Consistent with previous literature, we found that carriers of the MAOA-L polymorphism were more likely to take financial risks. Our computational choice model, rooted in established decision theory, showed that MAOA-L carriers exhibited such behaviour because they are able to make better financial decisions under risk, and not because they are more impulsive. In contrast, we found no behavioural or computational differences among the 5-HTT and DRD4 polymorphisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.